abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGDLVQPGGSLRLSCAASGSTLS	1 - 27	27
CDR-H1	IKAMA	28 - 32	5
HFR2	WYRQAPGKQREMVA	33 - 46	14
CDR-H2	AITSRGSPKYADSVKG	47 - 62	16
HFR3	RFTISRDNAKNTVSLQMNSLKPEDTAVYYCNA	63 - 94	32
CDR-H3	RTTFLTEGWRNY	95 - 106	12
HFR4	WGHGTQVT	107 - 114	8
			114

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGDLVQPGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGDLVQPGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGDLVQPGGSLRLSCAASGSTLS	1 - 27	27
	Contact	LQESGGDLVQPGGSLRLSCAASGSTL-	1 - 26	26
	IMGT	LQESGGDLVQPGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GSTLSIK---	23 - 29	7
	AbM	GSTLSIKAMA	23 - 32	10
	Kabat	-----IKAMA	28 - 32	5
	Contact	----SIKAMA	27 - 32	6
	IMGT	GSTLSIKA--	23 - 30	8
HFR2	Chothia	AMAWYRQAPGKQREMVAAI	30 - 48	19
	AbM	---WYRQAPGKQREMVA--	33 - 46	14
	Kabat	---WYRQAPGKQREMVA--	33 - 46	14
	Contact	---WYRQAPGKQRE-----	33 - 43	11
	IMGT	-MAWYRQAPGKQREMVAA-	31 - 47	17
CDR-H2	Chothia	-----TSRGS---------	49 - 53	5
	AbM	---AITSRGSPK-------	47 - 55	9
	Kabat	---AITSRGSPKYADSVKG	47 - 62	16
	Contact	MVAAITSRGSPK-------	44 - 55	12
	IMGT	----ITSRGSP--------	48 - 54	7
HFR3	Chothia	PKYADSVKGRFTISRDNAKNTVSLQMNSLKPEDTAVYYCNA	54 - 94	41
	AbM	--YADSVKGRFTISRDNAKNTVSLQMNSLKPEDTAVYYCNA	56 - 94	39
	Kabat	---------RFTISRDNAKNTVSLQMNSLKPEDTAVYYCNA	63 - 94	32
	Contact	--YADSVKGRFTISRDNAKNTVSLQMNSLKPEDTAVYYC--	56 - 92	37
	IMGT	-KYADSVKGRFTISRDNAKNTVSLQMNSLKPEDTAVYYC--	55 - 92	38
CDR-H3	Chothia	--RTTFLTEGWRNY	95 - 106	12
	AbM	--RTTFLTEGWRNY	95 - 106	12
	Kabat	--RTTFLTEGWRNY	95 - 106	12
	Contact	NARTTFLTEGWRN-	93 - 105	13
	IMGT	NARTTFLTEGWRNY	93 - 106	14
HFR4	Chothia	-WGHGTQVT	107 - 114	8
	AbM	-WGHGTQVT	107 - 114	8
	Kabat	-WGHGTQVT	107 - 114	8
	Contact	YWGHGTQVT	106 - 114	9
	IMGT	-WGHGTQVT	107 - 114	8

Accession & Annotations

Accession	CAH60927.1
Source	abYsis-EMBL-IG AJ849412 Submitted 12-OCT-2004 Updated 13-OCT-2004
Name	immunoglobulin heavy chain variable region
Clone	LT105
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (12-OCT-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M. 'Selection of llama single-domain antibody fragments binding to Escherichi a coli heat-labile enterotoxin' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQESGGDLVQPGGSLRLSCAASGSTLSIKAMAWYRQAPGKQREMVAAITSRGSPKYADSV
KGRFTISRDNAKNTVSLQMNSLKPEDTAVYYCNARTTFLTEGWRNYWGHGTQVT

DNA Sequence:

ctgcaggagtcagggggagacttggtgcagcctggggggtctctgagactctcctgtgca
gcctctggaagcaccctcagtatcaaggccatggcctggtaccgccaggctccggggaag
cagcgcgagatggtcgcagctattactagtcgtggtagcccaaagtatgcagactccgtg
aagggccgattcaccatctccagagacaacgccaagaacacggtgtctctgcaaatgaac
agcctgaaacctgaggacacggccgtttattactgtaatgcgcggactacgtttctgaca
gaaggttggcgtaactactggggccacgggacccaggttacc

Data Source:

Alignment settings:

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