abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQPGGSLRLSCAASGSFGY	1 - 27	27
CDR-H1	IGGMG	28 - 32	5
HFR2	WYRQTPGKQREFVA	33 - 46	14
CDR-H2	WITSDLSADYADSVKG	47 - 62	16
HFR3	RFTISRDNARHTVYLEMNNLKPEDTGVYYCNA	63 - 94	32
CDR-H3	RRPSSSTILDD	95 - 105	11
HFR4	WGQGTQVT	106 - 113	8
			113

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQPGGSLRLSCAASGSFGY	1 - 27	27
	Contact	LQESGGGLVQPGGSLRLSCAASGSFG-	1 - 26	26
	IMGT	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GSFGYIG---	23 - 29	7
	AbM	GSFGYIGGMG	23 - 32	10
	Kabat	-----IGGMG	28 - 32	5
	Contact	----YIGGMG	27 - 32	6
	IMGT	GSFGYIGG--	23 - 30	8
HFR2	Chothia	GMGWYRQTPGKQREFVAWI	30 - 48	19
	AbM	---WYRQTPGKQREFVA--	33 - 46	14
	Kabat	---WYRQTPGKQREFVA--	33 - 46	14
	Contact	---WYRQTPGKQRE-----	33 - 43	11
	IMGT	-MGWYRQTPGKQREFVAW-	31 - 47	17
CDR-H2	Chothia	-----TSDLS---------	49 - 53	5
	AbM	---WITSDLSAD-------	47 - 55	9
	Kabat	---WITSDLSADYADSVKG	47 - 62	16
	Contact	FVAWITSDLSAD-------	44 - 55	12
	IMGT	----ITSDLSA--------	48 - 54	7
HFR3	Chothia	ADYADSVKGRFTISRDNARHTVYLEMNNLKPEDTGVYYCNA	54 - 94	41
	AbM	--YADSVKGRFTISRDNARHTVYLEMNNLKPEDTGVYYCNA	56 - 94	39
	Kabat	---------RFTISRDNARHTVYLEMNNLKPEDTGVYYCNA	63 - 94	32
	Contact	--YADSVKGRFTISRDNARHTVYLEMNNLKPEDTGVYYC--	56 - 92	37
	IMGT	-DYADSVKGRFTISRDNARHTVYLEMNNLKPEDTGVYYC--	55 - 92	38
CDR-H3	Chothia	--RRPSSSTILDD	95 - 105	11
	AbM	--RRPSSSTILDD	95 - 105	11
	Kabat	--RRPSSSTILDD	95 - 105	11
	Contact	NARRPSSSTILD-	93 - 104	12
	IMGT	NARRPSSSTILDD	93 - 105	13
HFR4	Chothia	-WGQGTQVT	106 - 113	8
	AbM	-WGQGTQVT	106 - 113	8
	Kabat	-WGQGTQVT	106 - 113	8
	Contact	DWGQGTQVT	105 - 113	9
	IMGT	-WGQGTQVT	106 - 113	8

Accession & Annotations

Accession	CAH60928.1
Source	abYsis-EMBL-IG AJ849413 Submitted 12-OCT-2004 Updated 13-OCT-2004
Name	immunoglobulin heavy chain variable region
Clone	LT106
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (12-OCT-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M. 'Selection of llama single-domain antibody fragments binding to Escherichi a coli heat-labile enterotoxin' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQPGGSLRLSCAASGSFGYIGGMGWYRQTPGKQREFVAWITSDLSADYADSV
KGRFTISRDNARHTVYLEMNNLKPEDTGVYYCNARRPSSSTILDDWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactctcctgtgcg
gcctctggaagcttcgggtatatcggtggtatgggctggtaccgccagactccagggaag
cagcgcgagttcgtcgcgtggattactagcgatcttagcgcagactatgcagactccgtg
aagggccgattcacgatctccagagacaacgccaggcatacggtgtatttggaaatgaac
aacctgaaacctgaagacacgggcgtctattattgtaatgcacggcgacccagctcctct
accatccttgacgactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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