abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGSVQAGGSLRLSCAASASTFV	1 - 27	27
CDR-H1	INPMR	28 - 32	5
HFR2	WYRQAPGKQRELVA	33 - 46	14
CDR-H2	GITFNGATNYADSVKG	47 - 62	16
HFR3	RFTISNNNAKNTVFLQMNSLKPEDTAVYYCNV	63 - 94	32
CDR-H3	VVWVGSESYDY	95 - 105	11
HFR4	WGQGTQVT	106 - 113	8
			113

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGSVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQQSGGGSVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQQSGGGSVQAGGSLRLSCAASASTFV	1 - 27	27
	Contact	LQQSGGGSVQAGGSLRLSCAASASTF-	1 - 26	26
	IMGT	LQQSGGGSVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	ASTFVIN---	23 - 29	7
	AbM	ASTFVINPMR	23 - 32	10
	Kabat	-----INPMR	28 - 32	5
	Contact	----VINPMR	27 - 32	6
	IMGT	ASTFVINP--	23 - 30	8
HFR2	Chothia	PMRWYRQAPGKQRELVAGI	30 - 48	19
	AbM	---WYRQAPGKQRELVA--	33 - 46	14
	Kabat	---WYRQAPGKQRELVA--	33 - 46	14
	Contact	---WYRQAPGKQRE-----	33 - 43	11
	IMGT	-MRWYRQAPGKQRELVAG-	31 - 47	17
CDR-H2	Chothia	-----TFNGA---------	49 - 53	5
	AbM	---GITFNGATN-------	47 - 55	9
	Kabat	---GITFNGATNYADSVKG	47 - 62	16
	Contact	LVAGITFNGATN-------	44 - 55	12
	IMGT	----ITFNGAT--------	48 - 54	7
HFR3	Chothia	TNYADSVKGRFTISNNNAKNTVFLQMNSLKPEDTAVYYCNV	54 - 94	41
	AbM	--YADSVKGRFTISNNNAKNTVFLQMNSLKPEDTAVYYCNV	56 - 94	39
	Kabat	---------RFTISNNNAKNTVFLQMNSLKPEDTAVYYCNV	63 - 94	32
	Contact	--YADSVKGRFTISNNNAKNTVFLQMNSLKPEDTAVYYC--	56 - 92	37
	IMGT	-NYADSVKGRFTISNNNAKNTVFLQMNSLKPEDTAVYYC--	55 - 92	38
CDR-H3	Chothia	--VVWVGSESYDY	95 - 105	11
	AbM	--VVWVGSESYDY	95 - 105	11
	Kabat	--VVWVGSESYDY	95 - 105	11
	Contact	NVVVWVGSESYD-	93 - 104	12
	IMGT	NVVVWVGSESYDY	93 - 105	13
HFR4	Chothia	-WGQGTQVT	106 - 113	8
	AbM	-WGQGTQVT	106 - 113	8
	Kabat	-WGQGTQVT	106 - 113	8
	Contact	YWGQGTQVT	105 - 113	9
	IMGT	-WGQGTQVT	106 - 113	8

Accession & Annotations

Accession	CAH60939.1
Source	abYsis-EMBL-IG AJ849424 Submitted 12-OCT-2004 Updated 13-OCT-2004
Name	immunoglobulin heavy chain variable region
Clone	LT133
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (12-OCT-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M. 'Selection of llama single-domain antibody fragments binding to Escherichi a coli heat-labile enterotoxin' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQQSGGGSVQAGGSLRLSCAASASTFVINPMRWYRQAPGKQRELVAGITFNGATNYADSV
KGRFTISNNNAKNTVFLQMNSLKPEDTAVYYCNVVVWVGSESYDYWGQGTQVT

DNA Sequence:

ctgcagcagtcagggggaggctcggtgcaggctggggggtctctgagactctcctgtgca
gcctctgcaagcaccttcgttatcaatcccatgcgctggtaccgccaggctccagggaag
cagcgcgagttggtcgcaggaataacatttaatggtgcaacaaattatgcagactccgtg
aagggccgattcaccatctccaataacaacgccaagaacacagtgtttctgcaaatgaac
agcctgaaacctgaggacacggccgtctattactgtaatgtagttgtgtgggttggtagc
gagtcgtatgactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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