abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLACAASGTTVS	1 - 27	27
CDR-H1	SNTMD	28 - 32	5
HFR2	WHRQAPGKKRELVA	33 - 46	14
CDR-H2	RISRGDVLTYSDSVKG	47 - 62	16
HFR3	RFIISRDPTKNMVYLQMNELKPEDTAVYYCAA	63 - 94	32
CDR-H3	GLNIGTGIIPHKY	95 - 107	13
HFR4	WGQGTQVT	108 - 115	8
			115

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLACAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLACAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLACAASGTTVS	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLACAASGTTV-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLACAAS-----	1 - 22	22
CDR-H1	Chothia	GTTVSSN---	23 - 29	7
	AbM	GTTVSSNTMD	23 - 32	10
	Kabat	-----SNTMD	28 - 32	5
	Contact	----SSNTMD	27 - 32	6
	IMGT	GTTVSSNT--	23 - 30	8
HFR2	Chothia	TMDWHRQAPGKKRELVARI	30 - 48	19
	AbM	---WHRQAPGKKRELVA--	33 - 46	14
	Kabat	---WHRQAPGKKRELVA--	33 - 46	14
	Contact	---WHRQAPGKKRE-----	33 - 43	11
	IMGT	-MDWHRQAPGKKRELVAR-	31 - 47	17
CDR-H2	Chothia	-----SRGDV---------	49 - 53	5
	AbM	---RISRGDVLT-------	47 - 55	9
	Kabat	---RISRGDVLTYSDSVKG	47 - 62	16
	Contact	LVARISRGDVLT-------	44 - 55	12
	IMGT	----ISRGDVL--------	48 - 54	7
HFR3	Chothia	LTYSDSVKGRFIISRDPTKNMVYLQMNELKPEDTAVYYCAA	54 - 94	41
	AbM	--YSDSVKGRFIISRDPTKNMVYLQMNELKPEDTAVYYCAA	56 - 94	39
	Kabat	---------RFIISRDPTKNMVYLQMNELKPEDTAVYYCAA	63 - 94	32
	Contact	--YSDSVKGRFIISRDPTKNMVYLQMNELKPEDTAVYYC--	56 - 92	37
	IMGT	-TYSDSVKGRFIISRDPTKNMVYLQMNELKPEDTAVYYC--	55 - 92	38
CDR-H3	Chothia	--GLNIGTGIIPHKY	95 - 107	13
	AbM	--GLNIGTGIIPHKY	95 - 107	13
	Kabat	--GLNIGTGIIPHKY	95 - 107	13
	Contact	AAGLNIGTGIIPHK-	93 - 106	14
	IMGT	AAGLNIGTGIIPHKY	93 - 107	15
HFR4	Chothia	-WGQGTQVT	108 - 115	8
	AbM	-WGQGTQVT	108 - 115	8
	Kabat	-WGQGTQVT	108 - 115	8
	Contact	YWGQGTQVT	107 - 115	9
	IMGT	-WGQGTQVT	108 - 115	8

Accession & Annotations

Accession	CAH60941.1
Source	abYsis-EMBL-IG AJ849426 Submitted 12-OCT-2004 Updated 13-OCT-2004
Name	immunoglobulin heavy chain variable region
Clone	LT141
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (12-OCT-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M. 'Selection of llama single-domain antibody fragments binding to Escherichi a coli heat-labile enterotoxin' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLACAASGTTVSSNTMDWHRQAPGKKRELVARISRGDVLTYSDSV
KGRFIISRDPTKNMVYLQMNELKPEDTAVYYCAAGLNIGTGIIPHKYWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggcttggtgcaggctggggggtctctaagactcgcctgtgca
gcctccggaaccacggtcagtagtaataccatggactggcaccgccaggctccagggaag
aagcgcgagttggtcgcacgtatttccaggggtgatgttttaacttattcagactccgtg
aagggccgattcatcatctccagagatcccaccaagaacatggtgtatctgcaaatgaac
gaactgaaacctgaggacacagccgtctattattgtgcagcaggtctgaacataggcact
ggtatcattccacataagtactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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