abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQPGGSLRLSCAASGIIFR	1 - 27	27
CDR-H1	FNAMG	28 - 32	5
HFR2	WYRQEPGKQREFVA	33 - 46	14
CDR-H2	GISSGGTTINYADSVKG	47 - 63	17
HFR3	RFTISRDNTQKTVYLQMNSLKYDDTAVYFCAA	64 - 95	32
CDR-H3	YPGFQLTTPKW	96 - 106	11
HFR4	WGQGTQVT	107 - 114	8
			114

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQPGGSLRLSCAASGIIFR	1 - 27	27
	Contact	LQESGGGLVQPGGSLRLSCAASGIIF-	1 - 26	26
	IMGT	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GIIFRFN---	23 - 29	7
	AbM	GIIFRFNAMG	23 - 32	10
	Kabat	-----FNAMG	28 - 32	5
	Contact	----RFNAMG	27 - 32	6
	IMGT	GIIFRFNA--	23 - 30	8
HFR2	Chothia	AMGWYRQEPGKQREFVAGI	30 - 48	19
	AbM	---WYRQEPGKQREFVA--	33 - 46	14
	Kabat	---WYRQEPGKQREFVA--	33 - 46	14
	Contact	---WYRQEPGKQRE-----	33 - 43	11
	IMGT	-MGWYRQEPGKQREFVAG-	31 - 47	17
CDR-H2	Chothia	-----SSGGTT---------	49 - 54	6
	AbM	---GISSGGTTIN-------	47 - 56	10
	Kabat	---GISSGGTTINYADSVKG	47 - 63	17
	Contact	FVAGISSGGTTIN-------	44 - 56	13
	IMGT	----ISSGGTTI--------	48 - 55	8
HFR3	Chothia	INYADSVKGRFTISRDNTQKTVYLQMNSLKYDDTAVYFCAA	55 - 95	41
	AbM	--YADSVKGRFTISRDNTQKTVYLQMNSLKYDDTAVYFCAA	57 - 95	39
	Kabat	---------RFTISRDNTQKTVYLQMNSLKYDDTAVYFCAA	64 - 95	32
	Contact	--YADSVKGRFTISRDNTQKTVYLQMNSLKYDDTAVYFC--	57 - 93	37
	IMGT	-NYADSVKGRFTISRDNTQKTVYLQMNSLKYDDTAVYFC--	56 - 93	38
CDR-H3	Chothia	--YPGFQLTTPKW	96 - 106	11
	AbM	--YPGFQLTTPKW	96 - 106	11
	Kabat	--YPGFQLTTPKW	96 - 106	11
	Contact	AAYPGFQLTTPK-	94 - 105	12
	IMGT	AAYPGFQLTTPKW	94 - 106	13
HFR4	Chothia	-WGQGTQVT	107 - 114	8
	AbM	-WGQGTQVT	107 - 114	8
	Kabat	-WGQGTQVT	107 - 114	8
	Contact	WWGQGTQVT	106 - 114	9
	IMGT	-WGQGTQVT	107 - 114	8

Accession & Annotations

Accession	CAH60942.1
Source	abYsis-EMBL-IG AJ849427 Submitted 12-OCT-2004 Updated 13-OCT-2004
Name	immunoglobulin heavy chain variable region
Clone	LT143
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (12-OCT-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M. 'Selection of llama single-domain antibody fragments binding to Escherichi a coli heat-labile enterotoxin' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQPGGSLRLSCAASGIIFRFNAMGWYRQEPGKQREFVAGISSGGTTINYADS
VKGRFTISRDNTQKTVYLQMNSLKYDDTAVYFCAAYPGFQLTTPKWWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactctcctgtgca
gcctctggaatcatcttcaggttcaatgccatgggctggtaccgccaggagccagggaag
cagcgcgagttcgtcgcgggtataagtagcggtggtaccacgataaattatgcagactct
gtgaagggccgattcaccatctccagagacaacacccagaagacggtgtatctgcaaatg
aacagcctgaaatatgatgacacggccgtttatttctgtgcagcatatcccggtttccaa
cttacaactcctaagtggtggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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