abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQAGGSLRLSCAASGGSFS	1 - 27	27
CDR-H1	IYTMA	28 - 32	5
HFR2	WFRRAPGKDREFVA	33 - 46	14
CDR-H2	AISRSGGSWNGALTDYAESVKG	47 - 68	22
HFR3	RFTISRDSAENTVFLRMNSLKPEDTAIYYCAA	69 - 100	32
CDR-H3	DKTTFWNIPRDEYDY	101 - 115	15
HFR4	WGQGTLVT	116 - 123	8
			123

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQQSGGGLVQAGGSLRLSCAASGGSFS	1 - 27	27
	Contact	LQQSGGGLVQAGGSLRLSCAASGGSF-	1 - 26	26
	IMGT	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GGSFSIY---	23 - 29	7
	AbM	GGSFSIYTMA	23 - 32	10
	Kabat	-----IYTMA	28 - 32	5
	Contact	----SIYTMA	27 - 32	6
	IMGT	GGSFSIYT--	23 - 30	8
HFR2	Chothia	TMAWFRRAPGKDREFVAAI	30 - 48	19
	AbM	---WFRRAPGKDREFVA--	33 - 46	14
	Kabat	---WFRRAPGKDREFVA--	33 - 46	14
	Contact	---WFRRAPGKDRE-----	33 - 43	11
	IMGT	-MAWFRRAPGKDREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SRSGGSWNGAL---------	49 - 59	11
	AbM	---AISRSGGSWNGALTD-------	47 - 61	15
	Kabat	---AISRSGGSWNGALTDYAESVKG	47 - 68	22
	Contact	FVAAISRSGGSWNGALTD-------	44 - 61	18
	IMGT	----ISRSGGSWNGALT--------	48 - 60	13
HFR3	Chothia	TDYAESVKGRFTISRDSAENTVFLRMNSLKPEDTAIYYCAA	60 - 100	41
	AbM	--YAESVKGRFTISRDSAENTVFLRMNSLKPEDTAIYYCAA	62 - 100	39
	Kabat	---------RFTISRDSAENTVFLRMNSLKPEDTAIYYCAA	69 - 100	32
	Contact	--YAESVKGRFTISRDSAENTVFLRMNSLKPEDTAIYYC--	62 - 98	37
	IMGT	-DYAESVKGRFTISRDSAENTVFLRMNSLKPEDTAIYYC--	61 - 98	38
CDR-H3	Chothia	--DKTTFWNIPRDEYDY	101 - 115	15
	AbM	--DKTTFWNIPRDEYDY	101 - 115	15
	Kabat	--DKTTFWNIPRDEYDY	101 - 115	15
	Contact	AADKTTFWNIPRDEYD-	99 - 114	16
	IMGT	AADKTTFWNIPRDEYDY	99 - 115	17
HFR4	Chothia	-WGQGTLVT	116 - 123	8
	AbM	-WGQGTLVT	116 - 123	8
	Kabat	-WGQGTLVT	116 - 123	8
	Contact	YWGQGTLVT	115 - 123	9
	IMGT	-WGQGTLVT	116 - 123	8

Accession & Annotations

Accession	CAH60945.1
Source	abYsis-EMBL-IG AJ849430 Submitted 12-OCT-2004 Updated 13-OCT-2004
Name	immunoglobulin heavy chain variable region
Clone	LT153
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (12-OCT-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M. 'Selection of llama single-domain antibody fragments binding to Escherichi a coli heat-labile enterotoxin' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQAGGSLRLSCAASGGSFSIYTMAWFRRAPGKDREFVAAISRSGGSWNGALT
DYAESVKGRFTISRDSAENTVFLRMNSLKPEDTAIYYCAADKTTFWNIPRDEYDYWGQGT
LVT

DNA Sequence:

ctgcagcagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggcggctccttcagtatctataccatggcctggtttcgccgggctccagggaag
gaccgtgagtttgtagcagctattagtcggagtggtggtagctggaatggtgcgctgaca
gactatgcagagtccgtgaagggccgattcaccatctccagagacagcgccgagaacacg
gtgtttctgcgcatgaatagcctgaaacctgaggacacggccatttattactgtgcagca
gacaaaacaacgttttggaatattcctcgggatgagtatgactactggggccaggggacc
ttggtcacc

Data Source:

Alignment settings:

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