abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGGTES	1 - 27	27
CDR-H1	IVTMA	28 - 32	5
HFR2	WFRQAVGKEREFVA	33 - 46	14
CDR-H2	AITRSGASWTTGAMTDYADSVKG	47 - 69	23
HFR3	RFTISRDNAKNTVYLQMNSLKLEDTAVYYCLA	70 - 101	32
CDR-H3	DKTTYWNIPRDEYDY	102 - 116	15
HFR4	WGQGTQVT	117 - 124	8
			124

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGGTES	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGGTE-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GGTESIV---	23 - 29	7
	AbM	GGTESIVTMA	23 - 32	10
	Kabat	-----IVTMA	28 - 32	5
	Contact	----SIVTMA	27 - 32	6
	IMGT	GGTESIVT--	23 - 30	8
HFR2	Chothia	TMAWFRQAVGKEREFVAAI	30 - 48	19
	AbM	---WFRQAVGKEREFVA--	33 - 46	14
	Kabat	---WFRQAVGKEREFVA--	33 - 46	14
	Contact	---WFRQAVGKERE-----	33 - 43	11
	IMGT	-MAWFRQAVGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----TRSGASWTTGAM---------	49 - 60	12
	AbM	---AITRSGASWTTGAMTD-------	47 - 62	16
	Kabat	---AITRSGASWTTGAMTDYADSVKG	47 - 69	23
	Contact	FVAAITRSGASWTTGAMTD-------	44 - 62	19
	IMGT	----ITRSGASWTTGAMT--------	48 - 61	14
HFR3	Chothia	TDYADSVKGRFTISRDNAKNTVYLQMNSLKLEDTAVYYCLA	61 - 101	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLKLEDTAVYYCLA	63 - 101	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKLEDTAVYYCLA	70 - 101	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLKLEDTAVYYC--	63 - 99	37
	IMGT	-DYADSVKGRFTISRDNAKNTVYLQMNSLKLEDTAVYYC--	62 - 99	38
CDR-H3	Chothia	--DKTTYWNIPRDEYDY	102 - 116	15
	AbM	--DKTTYWNIPRDEYDY	102 - 116	15
	Kabat	--DKTTYWNIPRDEYDY	102 - 116	15
	Contact	LADKTTYWNIPRDEYD-	100 - 115	16
	IMGT	LADKTTYWNIPRDEYDY	100 - 116	17
HFR4	Chothia	-WGQGTQVT	117 - 124	8
	AbM	-WGQGTQVT	117 - 124	8
	Kabat	-WGQGTQVT	117 - 124	8
	Contact	YWGQGTQVT	116 - 124	9
	IMGT	-WGQGTQVT	117 - 124	8

Accession & Annotations

Accession	CAH60951.1
Source	abYsis-EMBL-IG AJ849436 Submitted 12-OCT-2004 Updated 13-OCT-2004
Name	immunoglobulin heavy chain variable region
Clone	LT165
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (12-OCT-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M. 'Selection of llama single-domain antibody fragments binding to Escherichi a coli heat-labile enterotoxin' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGGTESIVTMAWFRQAVGKEREFVAAITRSGASWTTGAM
TDYADSVKGRFTISRDNAKNTVYLQMNSLKLEDTAVYYCLADKTTYWNIPRDEYDYWGQG
TQVT

DNA Sequence:

ctgcaggagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggcggcaccgaaagtatcgttaccatggcgtggttccgccaggctgtagggaag
gagcgtgagtttgtagcggctattacacggagcggcgctagctggacgactggtgctatg
acggactatgcagactccgtgaagggccgattcaccatctccagagacaacgccaagaac
acggtgtatctgcaaatgaacagcctgaaacttgaggacacggccgtttattactgttta
gcagacaaaactacgtattggaatattccccgggatgagtatgactactggggccagggg
acccaggtcacc

Data Source:

Alignment settings:

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