abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGGTFS	1 - 27	27
CDR-H1	IYTMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AITRSGISWKGAMTDYGDSVKG	47 - 68	22
HFR3	RFTISGDNAKNTVFLQMNSLKPEDTAMYYCAA	69 - 100	32
CDR-H3	DKTTYWNIPRDEYDF	101 - 115	15
HFR4	WGQGTQVT	116 - 123	8
			123

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGGTFS	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGGTF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GGTFSIY---	23 - 29	7
	AbM	GGTFSIYTMG	23 - 32	10
	Kabat	-----IYTMG	28 - 32	5
	Contact	----SIYTMG	27 - 32	6
	IMGT	GGTFSIYT--	23 - 30	8
HFR2	Chothia	TMGWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----TRSGISWKGAM---------	49 - 59	11
	AbM	---AITRSGISWKGAMTD-------	47 - 61	15
	Kabat	---AITRSGISWKGAMTDYGDSVKG	47 - 68	22
	Contact	FVAAITRSGISWKGAMTD-------	44 - 61	18
	IMGT	----ITRSGISWKGAMT--------	48 - 60	13
HFR3	Chothia	TDYGDSVKGRFTISGDNAKNTVFLQMNSLKPEDTAMYYCAA	60 - 100	41
	AbM	--YGDSVKGRFTISGDNAKNTVFLQMNSLKPEDTAMYYCAA	62 - 100	39
	Kabat	---------RFTISGDNAKNTVFLQMNSLKPEDTAMYYCAA	69 - 100	32
	Contact	--YGDSVKGRFTISGDNAKNTVFLQMNSLKPEDTAMYYC--	62 - 98	37
	IMGT	-DYGDSVKGRFTISGDNAKNTVFLQMNSLKPEDTAMYYC--	61 - 98	38
CDR-H3	Chothia	--DKTTYWNIPRDEYDF	101 - 115	15
	AbM	--DKTTYWNIPRDEYDF	101 - 115	15
	Kabat	--DKTTYWNIPRDEYDF	101 - 115	15
	Contact	AADKTTYWNIPRDEYD-	99 - 114	16
	IMGT	AADKTTYWNIPRDEYDF	99 - 115	17
HFR4	Chothia	-WGQGTQVT	116 - 123	8
	AbM	-WGQGTQVT	116 - 123	8
	Kabat	-WGQGTQVT	116 - 123	8
	Contact	FWGQGTQVT	115 - 123	9
	IMGT	-WGQGTQVT	116 - 123	8

Accession & Annotations

Accession	CAH60956.1
Source	abYsis-EMBL-IG AJ849441 Submitted 12-OCT-2004 Updated 13-OCT-2004
Name	immunoglobulin heavy chain variable region
Clone	LT175
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	abYsis-EMBL-IG: CAH60925.1 CAH60943.1 CAH60944.1
References	Harmsen M.M. Submitted (12-OCT-2004) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M. 'Selection of llama single-domain antibody fragments binding to Escherichi a coli heat-labile enterotoxin' Unpublished.

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGGTFSIYTMGWFRQAPGKEREFVAAITRSGISWKGAMT
DYGDSVKGRFTISGDNAKNTVFLQMNSLKPEDTAMYYCAADKTTYWNIPRDEYDFWGQGT
QVT

DNA Sequence:

ctgcaggagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggcggcaccttcagtatctataccatgggctggttccgccaggctccagggaag
gagcgtgagtttgtagcggctattactaggagtggtatcagctggaaaggtgcaatgaca
gactatggagactccgtgaagggccgattcaccatctccggagacaacgccaagaacacg
gtgtttctgcaaatgaacagcctgaaacctgaggacacggccatgtattattgtgcagca
gacaaaacaacgtattggaatattcctcgggatgagtatgacttctggggccaggggacc
caggtcacc

Data Source:

Alignment settings:

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