abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQAGGSLRLSCAASGRAFQ	1 - 27	27
CDR-H1	HYYMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AISWYDGSPSYADSVKG	47 - 63	17
HFR3	RFTIYRDNAKNTVDLQISSLKSEDTAVYYCVG	64 - 95	32
CDR-H3	DRGLTAVASSWRY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQQSGGGLVQAGGSLRLSCAASGRAFQ	1 - 27	27
	Contact	LQQSGGGLVQAGGSLRLSCAASGRAF-	1 - 26	26
	IMGT	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRAFQHY---	23 - 29	7
	AbM	GRAFQHYYMG	23 - 32	10
	Kabat	-----HYYMG	28 - 32	5
	Contact	----QHYYMG	27 - 32	6
	IMGT	GRAFQHYY--	23 - 30	8
HFR2	Chothia	YMGWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWYDGS---------	49 - 54	6
	AbM	---AISWYDGSPS-------	47 - 56	10
	Kabat	---AISWYDGSPSYADSVKG	47 - 63	17
	Contact	FVAAISWYDGSPS-------	44 - 56	13
	IMGT	----ISWYDGSP--------	48 - 55	8
HFR3	Chothia	PSYADSVKGRFTIYRDNAKNTVDLQISSLKSEDTAVYYCVG	55 - 95	41
	AbM	--YADSVKGRFTIYRDNAKNTVDLQISSLKSEDTAVYYCVG	57 - 95	39
	Kabat	---------RFTIYRDNAKNTVDLQISSLKSEDTAVYYCVG	64 - 95	32
	Contact	--YADSVKGRFTIYRDNAKNTVDLQISSLKSEDTAVYYC--	57 - 93	37
	IMGT	-SYADSVKGRFTIYRDNAKNTVDLQISSLKSEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DRGLTAVASSWRY	96 - 108	13
	AbM	--DRGLTAVASSWRY	96 - 108	13
	Kabat	--DRGLTAVASSWRY	96 - 108	13
	Contact	VGDRGLTAVASSWR-	94 - 107	14
	IMGT	VGDRGLTAVASSWRY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55263.1
Source	abYsis-EMBL-IG AM180268 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M10
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQAGGSLRLSCAASGRAFQHYYMGWFRQAPGKEREFVAAISWYDGSPSYADS
VKGRFTIYRDNAKNTVDLQISSLKSEDTAVYYCVGDRGLTAVASSWRYWGQGTQVT

DNA Sequence:

ctgcagcagtcagggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcgccttccagcactattacatgggatggttccgccaggctccaggaaag
gagcgtgagtttgtagcagctattagctggtatgatggtagcccatcgtatgcagactcc
gtgaagggccgattcaccatctacagagacaacgccaagaacacggtagatctgcaaata
agcagcctgaaatctgaggacacggccgtttattactgtgtaggagatcgtggtttgacg
gctgtagcaagttcctggagatactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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