abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASRLIFN	1 - 27	27
CDR-H1	NHYLG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AISWYDGSTSYADSVKG	47 - 63	17
HFR3	RFTISRDSAKNTVDLQMNSLKSEDTAVYYCAG	64 - 95	32
CDR-H3	DRGLTASPSSWRY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASRLIFN	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASRLIF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	RLIFNNH---	23 - 29	7
	AbM	RLIFNNHYLG	23 - 32	10
	Kabat	-----NHYLG	28 - 32	5
	Contact	----NNHYLG	27 - 32	6
	IMGT	RLIFNNHY--	23 - 30	8
HFR2	Chothia	YLGWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-LGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWYDGS---------	49 - 54	6
	AbM	---AISWYDGSTS-------	47 - 56	10
	Kabat	---AISWYDGSTSYADSVKG	47 - 63	17
	Contact	FVAAISWYDGSTS-------	44 - 56	13
	IMGT	----ISWYDGST--------	48 - 55	8
HFR3	Chothia	TSYADSVKGRFTISRDSAKNTVDLQMNSLKSEDTAVYYCAG	55 - 95	41
	AbM	--YADSVKGRFTISRDSAKNTVDLQMNSLKSEDTAVYYCAG	57 - 95	39
	Kabat	---------RFTISRDSAKNTVDLQMNSLKSEDTAVYYCAG	64 - 95	32
	Contact	--YADSVKGRFTISRDSAKNTVDLQMNSLKSEDTAVYYC--	57 - 93	37
	IMGT	-SYADSVKGRFTISRDSAKNTVDLQMNSLKSEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DRGLTASPSSWRY	96 - 108	13
	AbM	--DRGLTASPSSWRY	96 - 108	13
	Kabat	--DRGLTASPSSWRY	96 - 108	13
	Contact	AGDRGLTASPSSWR-	94 - 107	14
	IMGT	AGDRGLTASPSSWRY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55264.1
Source	abYsis-EMBL-IG AM180269 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M11
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASRLIFNNHYLGWFRQAPGKEREFVAAISWYDGSTSYADS
VKGRFTISRDSAKNTVDLQMNSLKSEDTAVYYCAGDRGLTASPSSWRYWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctcgactcatcttcaataatcattacttgggctggttccgccaggctccagggaag
gagcgtgagtttgtagcagctattagctggtatgatggtagcacatcgtatgcagactcc
gtgaagggccgattcaccatctccagagacagcgccaaaaacacggtggatctgcaaatg
aacagtctgaaatctgaggacacggccgtttattattgtgcaggagatcgtggtttgacg
gcatcaccaagttcttggaggtactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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