abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGLTFS	1 - 27	27
CDR-H1	SYYMG	28 - 32	5
HFR2	WFRQTPGKEREFVA	33 - 46	14
CDR-H2	AIGWYDDSTSYADSVKN	47 - 63	17
HFR3	RFTISRDNAKNTVYLQMSSLKPEDTAVYYCAG	64 - 95	32
CDR-H3	GRSLTVVASSWRY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGLTFS	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGLTF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GLTFSSY---	23 - 29	7
	AbM	GLTFSSYYMG	23 - 32	10
	Kabat	-----SYYMG	28 - 32	5
	Contact	----SSYYMG	27 - 32	6
	IMGT	GLTFSSYY--	23 - 30	8
HFR2	Chothia	YMGWFRQTPGKEREFVAAI	30 - 48	19
	AbM	---WFRQTPGKEREFVA--	33 - 46	14
	Kabat	---WFRQTPGKEREFVA--	33 - 46	14
	Contact	---WFRQTPGKERE-----	33 - 43	11
	IMGT	-MGWFRQTPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----GWYDDS---------	49 - 54	6
	AbM	---AIGWYDDSTS-------	47 - 56	10
	Kabat	---AIGWYDDSTSYADSVKN	47 - 63	17
	Contact	FVAAIGWYDDSTS-------	44 - 56	13
	IMGT	----IGWYDDST--------	48 - 55	8
HFR3	Chothia	TSYADSVKNRFTISRDNAKNTVYLQMSSLKPEDTAVYYCAG	55 - 95	41
	AbM	--YADSVKNRFTISRDNAKNTVYLQMSSLKPEDTAVYYCAG	57 - 95	39
	Kabat	---------RFTISRDNAKNTVYLQMSSLKPEDTAVYYCAG	64 - 95	32
	Contact	--YADSVKNRFTISRDNAKNTVYLQMSSLKPEDTAVYYC--	57 - 93	37
	IMGT	-SYADSVKNRFTISRDNAKNTVYLQMSSLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--GRSLTVVASSWRY	96 - 108	13
	AbM	--GRSLTVVASSWRY	96 - 108	13
	Kabat	--GRSLTVVASSWRY	96 - 108	13
	Contact	AGGRSLTVVASSWR-	94 - 107	14
	IMGT	AGGRSLTVVASSWRY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55266.1
Source	abYsis-EMBL-IG AM180271 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M66
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGLTFSSYYMGWFRQTPGKEREFVAAIGWYDDSTSYADS
VKNRFTISRDNAKNTVYLQMSSLKPEDTAVYYCAGGRSLTVVASSWRYWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggactcaccttcagtagctattacatgggctggttccgccagactccagggaag
gagcgtgagtttgtagcagctattggctggtatgatgatagcacatcttatgcagactcc
gtgaagaaccgattcaccatctccagagacaacgccaagaacacggtgtatctgcaaatg
agcagcctgaaacctgaggacacggccgtttattactgtgcaggaggtcgtagtttgacg
gtggtagctagttcctggaggtactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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