abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGRAFQ	1 - 27	27
CDR-H1	YYYTA	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AISWYDGSTSYADSVKG	47 - 63	17
HFR3	RFTISRDNAENTVDLQMNSLKSEDTAVYYCAG	64 - 95	32
CDR-H3	DRGLTAVASSWRY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGRAFQ	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGRAF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRAFQYY---	23 - 29	7
	AbM	GRAFQYYYTA	23 - 32	10
	Kabat	-----YYYTA	28 - 32	5
	Contact	----QYYYTA	27 - 32	6
	IMGT	GRAFQYYY--	23 - 30	8
HFR2	Chothia	YTAWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-TAWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWYDGS---------	49 - 54	6
	AbM	---AISWYDGSTS-------	47 - 56	10
	Kabat	---AISWYDGSTSYADSVKG	47 - 63	17
	Contact	FVAAISWYDGSTS-------	44 - 56	13
	IMGT	----ISWYDGST--------	48 - 55	8
HFR3	Chothia	TSYADSVKGRFTISRDNAENTVDLQMNSLKSEDTAVYYCAG	55 - 95	41
	AbM	--YADSVKGRFTISRDNAENTVDLQMNSLKSEDTAVYYCAG	57 - 95	39
	Kabat	---------RFTISRDNAENTVDLQMNSLKSEDTAVYYCAG	64 - 95	32
	Contact	--YADSVKGRFTISRDNAENTVDLQMNSLKSEDTAVYYC--	57 - 93	37
	IMGT	-SYADSVKGRFTISRDNAENTVDLQMNSLKSEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DRGLTAVASSWRY	96 - 108	13
	AbM	--DRGLTAVASSWRY	96 - 108	13
	Kabat	--DRGLTAVASSWRY	96 - 108	13
	Contact	AGDRGLTAVASSWR-	94 - 107	14
	IMGT	AGDRGLTAVASSWRY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55267.1
Source	abYsis-EMBL-IG AM180272 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M71
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGRAFQYYYTAWFRQAPGKEREFVAAISWYDGSTSYADS
VKGRFTISRDNAENTVDLQMNSLKSEDTAVYYCAGDRGLTAVASSWRYWGQGTQVT

DNA Sequence:

ctgcaggagtcagggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcgccttccagtactattacacggcatggttccgccaggctccaggaaag
gagcgtgagtttgtagcagctattagttggtatgatggtagcacatcgtatgcagactcc
gtgaagggccgattcaccatctccagagacaacgccgagaacacggtagatctgcaaatg
aacagcctgaaatctgaggacacggccgtttattactgtgcaggagatcgtggtttgacg
gcagtagcaagttcctggaggtactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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