abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQTGGSLRLSCAASGRIFN	1 - 27	27
CDR-H1	HYYMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AISWYDGSTSYADSVKG	47 - 63	17
HFR3	RFTVSRDNAKNTVDLQMNSLESEDTAVYYCVG	64 - 95	32
CDR-H3	DRGLTAVASSWRY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQTGGSLRLSCAAS-----	1 - 22	22
	AbM	LQQSGGGLVQTGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQQSGGGLVQTGGSLRLSCAASGRIFN	1 - 27	27
	Contact	LQQSGGGLVQTGGSLRLSCAASGRIF-	1 - 26	26
	IMGT	LQQSGGGLVQTGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRIFNHY---	23 - 29	7
	AbM	GRIFNHYYMG	23 - 32	10
	Kabat	-----HYYMG	28 - 32	5
	Contact	----NHYYMG	27 - 32	6
	IMGT	GRIFNHYY--	23 - 30	8
HFR2	Chothia	YMGWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWYDGS---------	49 - 54	6
	AbM	---AISWYDGSTS-------	47 - 56	10
	Kabat	---AISWYDGSTSYADSVKG	47 - 63	17
	Contact	FVAAISWYDGSTS-------	44 - 56	13
	IMGT	----ISWYDGST--------	48 - 55	8
HFR3	Chothia	TSYADSVKGRFTVSRDNAKNTVDLQMNSLESEDTAVYYCVG	55 - 95	41
	AbM	--YADSVKGRFTVSRDNAKNTVDLQMNSLESEDTAVYYCVG	57 - 95	39
	Kabat	---------RFTVSRDNAKNTVDLQMNSLESEDTAVYYCVG	64 - 95	32
	Contact	--YADSVKGRFTVSRDNAKNTVDLQMNSLESEDTAVYYC--	57 - 93	37
	IMGT	-SYADSVKGRFTVSRDNAKNTVDLQMNSLESEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DRGLTAVASSWRY	96 - 108	13
	AbM	--DRGLTAVASSWRY	96 - 108	13
	Kabat	--DRGLTAVASSWRY	96 - 108	13
	Contact	VGDRGLTAVASSWR-	94 - 107	14
	IMGT	VGDRGLTAVASSWRY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55269.1
Source	abYsis-EMBL-IG AM180274 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M74
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQTGGSLRLSCAASGRIFNHYYMGWFRQAPGKEREFVAAISWYDGSTSYADS
VKGRFTVSRDNAKNTVDLQMNSLESEDTAVYYCVGDRGLTAVASSWRYWGQGTQVT

DNA Sequence:

ctgcagcagtctgggggaggattggtgcaaactgggggctctctgagactgtcctgtgca
gcctctggacgcattttcaaccactattacatgggctggttccgccaggctccagggaag
gagcgtgagtttgtagcagctattagctggtatgatggtagcacatcgtatgcagactcc
gtgaagggccgattcaccgtctccagagacaacgccaaaaacacggtagatctgcaaatg
aacagcctggaatctgaggacacggccgtttattactgtgtaggagatcgtggtttgacg
gcagtagcaagttcctggaggtactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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