abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGLTFS	1 - 27	27
CDR-H1	RYYLA	28 - 32	5
HFR2	WFRQAPGKERELVA	33 - 46	14
CDR-H2	TIGWYDYSTYYADSVKG	47 - 63	17
HFR3	RFTISRDNAKNTMYLQVNSLKPEDTAVYYCAG	64 - 95	32
CDR-H3	GRSLTDVPGSWSY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGLTFS	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGLTF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GLTFSRY---	23 - 29	7
	AbM	GLTFSRYYLA	23 - 32	10
	Kabat	-----RYYLA	28 - 32	5
	Contact	----SRYYLA	27 - 32	6
	IMGT	GLTFSRYY--	23 - 30	8
HFR2	Chothia	YLAWFRQAPGKERELVATI	30 - 48	19
	AbM	---WFRQAPGKERELVA--	33 - 46	14
	Kabat	---WFRQAPGKERELVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-LAWFRQAPGKERELVAT-	31 - 47	17
CDR-H2	Chothia	-----GWYDYS---------	49 - 54	6
	AbM	---TIGWYDYSTY-------	47 - 56	10
	Kabat	---TIGWYDYSTYYADSVKG	47 - 63	17
	Contact	LVATIGWYDYSTY-------	44 - 56	13
	IMGT	----IGWYDYST--------	48 - 55	8
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTMYLQVNSLKPEDTAVYYCAG	55 - 95	41
	AbM	--YADSVKGRFTISRDNAKNTMYLQVNSLKPEDTAVYYCAG	57 - 95	39
	Kabat	---------RFTISRDNAKNTMYLQVNSLKPEDTAVYYCAG	64 - 95	32
	Contact	--YADSVKGRFTISRDNAKNTMYLQVNSLKPEDTAVYYC--	57 - 93	37
	IMGT	-YYADSVKGRFTISRDNAKNTMYLQVNSLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--GRSLTDVPGSWSY	96 - 108	13
	AbM	--GRSLTDVPGSWSY	96 - 108	13
	Kabat	--GRSLTDVPGSWSY	96 - 108	13
	Contact	AGGRSLTDVPGSWS-	94 - 107	14
	IMGT	AGGRSLTDVPGSWSY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55270.1
Source	abYsis-EMBL-IG AM180275 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M75
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGLTFSRYYLAWFRQAPGKERELVATIGWYDYSTYYADS
VKGRFTISRDNAKNTMYLQVNSLKPEDTAVYYCAGGRSLTDVPGSWSYWGQGTQVT

DNA Sequence:

ctgcaggagtcagggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggactcaccttcagtaggtattacttggcctggttccgccaggctccagggaag
gagcgcgagcttgtagcaactattggctggtatgactattctacatactatgcagactcc
gtgaagggccgattcaccatctccagagacaacgccaagaacactatgtatctgcaagtg
aacagcctgaaacctgaggacacggccgtttattactgtgcaggaggtcgtagtttgacg
gacgtacctggttcctggagctactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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