abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGRAFG	1 - 27	27
CDR-H1	YYYMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AISWYDGSTSYADSVKG	47 - 63	17
HFR3	RFTISRDNAKNTVYLQMNSLKSEDTAVYYCAG	64 - 95	32
CDR-H3	DRSLTVVASSWRY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGRAFG	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGRAF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRAFGYY---	23 - 29	7
	AbM	GRAFGYYYMG	23 - 32	10
	Kabat	-----YYYMG	28 - 32	5
	Contact	----GYYYMG	27 - 32	6
	IMGT	GRAFGYYY--	23 - 30	8
HFR2	Chothia	YMGWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWYDGS---------	49 - 54	6
	AbM	---AISWYDGSTS-------	47 - 56	10
	Kabat	---AISWYDGSTSYADSVKG	47 - 63	17
	Contact	FVAAISWYDGSTS-------	44 - 56	13
	IMGT	----ISWYDGST--------	48 - 55	8
HFR3	Chothia	TSYADSVKGRFTISRDNAKNTVYLQMNSLKSEDTAVYYCAG	55 - 95	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLKSEDTAVYYCAG	57 - 95	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKSEDTAVYYCAG	64 - 95	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLKSEDTAVYYC--	57 - 93	37
	IMGT	-SYADSVKGRFTISRDNAKNTVYLQMNSLKSEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DRSLTVVASSWRY	96 - 108	13
	AbM	--DRSLTVVASSWRY	96 - 108	13
	Kabat	--DRSLTVVASSWRY	96 - 108	13
	Contact	AGDRSLTVVASSWR-	94 - 107	14
	IMGT	AGDRSLTVVASSWRY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55271.1
Source	abYsis-EMBL-IG AM180276 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M76
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGRAFGYYYMGWFRQAPGKEREFVAAISWYDGSTSYADS
VKGRFTISRDNAKNTVYLQMNSLKSEDTAVYYCAGDRSLTVVASSWRYWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgggccttcggatactattacatgggctggttccgccaggctccagggaag
gagcgtgagtttgtagcagctattagctggtatgatggtagcacatcttatgcagactcc
gtgaagggccgattcaccatctccagagacaacgccaagaacacggtgtatctgcaaatg
aacagcctgaaatctgaggacacggccgtttattactgtgcaggagatcgtagtttgacg
gtagtagcaagttcctggaggtactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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