abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQAGGSLRLSCQASHPSFN	1 - 27	27
CDR-H1	HYYMG	28 - 32	5
HFR2	WFRQAPGKNREFVA	33 - 46	14
CDR-H2	AISWYDHSTSYADSVKG	47 - 63	17
HFR3	RFTISRDNAKNTVDLQMNSLKSEDTAVYYCVG	64 - 95	32
CDR-H3	DRGLTAVASSWRY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQAGGSLRLSCQAS-----	1 - 22	22
	AbM	LQQSGGGLVQAGGSLRLSCQAS-----	1 - 22	22
	Kabat	LQQSGGGLVQAGGSLRLSCQASHPSFN	1 - 27	27
	Contact	LQQSGGGLVQAGGSLRLSCQASHPSF-	1 - 26	26
	IMGT	LQQSGGGLVQAGGSLRLSCQAS-----	1 - 22	22
CDR-H1	Chothia	HPSFNHY---	23 - 29	7
	AbM	HPSFNHYYMG	23 - 32	10
	Kabat	-----HYYMG	28 - 32	5
	Contact	----NHYYMG	27 - 32	6
	IMGT	HPSFNHYY--	23 - 30	8
HFR2	Chothia	YMGWFRQAPGKNREFVAAI	30 - 48	19
	AbM	---WFRQAPGKNREFVA--	33 - 46	14
	Kabat	---WFRQAPGKNREFVA--	33 - 46	14
	Contact	---WFRQAPGKNRE-----	33 - 43	11
	IMGT	-MGWFRQAPGKNREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWYDHS---------	49 - 54	6
	AbM	---AISWYDHSTS-------	47 - 56	10
	Kabat	---AISWYDHSTSYADSVKG	47 - 63	17
	Contact	FVAAISWYDHSTS-------	44 - 56	13
	IMGT	----ISWYDHST--------	48 - 55	8
HFR3	Chothia	TSYADSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCVG	55 - 95	41
	AbM	--YADSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCVG	57 - 95	39
	Kabat	---------RFTISRDNAKNTVDLQMNSLKSEDTAVYYCVG	64 - 95	32
	Contact	--YADSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYC--	57 - 93	37
	IMGT	-SYADSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DRGLTAVASSWRY	96 - 108	13
	AbM	--DRGLTAVASSWRY	96 - 108	13
	Kabat	--DRGLTAVASSWRY	96 - 108	13
	Contact	VGDRGLTAVASSWR-	94 - 107	14
	IMGT	VGDRGLTAVASSWRY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55272.1
Source	abYsis-EMBL-IG AM180277 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M78
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQAGGSLRLSCQASHPSFNHYYMGWFRQAPGKNREFVAAISWYDHSTSYADS
VKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCVGDRGLTAVASSWRYWGQGTQVT

DNA Sequence:

ctgcagcagtcagggggaggattggtgcaggctgggggctctctgagactctcctgtcaa
gcctctcacccctccttcaatcactattacatgggctggttccgccaggctccagggaag
aaccgtgagtttgtagcagctattagctggtatgatcatagcacatcgtatgcagactcc
gtgaagggccgattcaccatctccagagacaacgccaaaaacacggtggatctgcaaatg
aacagcctgaaatctgaggacacggccgtttattactgtgtaggagatcgtggtttgacg
gctgtagcaagttcctggagatactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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