abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQAGGSLRLSCVVSGRIFN	1 - 27	27
CDR-H1	NHYMG	28 - 32	5
HFR2	WFRQAPGKEREFLA	33 - 46	14
CDR-H2	AISWYDGSTSYADSVKG	47 - 63	17
HFR3	RFTISRVNAKNTVDLQMNSLKSEDTAVYYCAG	64 - 95	32
CDR-H3	DRGLTAVASSWRY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQAGGSLRLSCVVS-----	1 - 22	22
	AbM	LQQSGGGLVQAGGSLRLSCVVS-----	1 - 22	22
	Kabat	LQQSGGGLVQAGGSLRLSCVVSGRIFN	1 - 27	27
	Contact	LQQSGGGLVQAGGSLRLSCVVSGRIF-	1 - 26	26
	IMGT	LQQSGGGLVQAGGSLRLSCVVS-----	1 - 22	22
CDR-H1	Chothia	GRIFNNH---	23 - 29	7
	AbM	GRIFNNHYMG	23 - 32	10
	Kabat	-----NHYMG	28 - 32	5
	Contact	----NNHYMG	27 - 32	6
	IMGT	GRIFNNHY--	23 - 30	8
HFR2	Chothia	YMGWFRQAPGKEREFLAAI	30 - 48	19
	AbM	---WFRQAPGKEREFLA--	33 - 46	14
	Kabat	---WFRQAPGKEREFLA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFLAA-	31 - 47	17
CDR-H2	Chothia	-----SWYDGS---------	49 - 54	6
	AbM	---AISWYDGSTS-------	47 - 56	10
	Kabat	---AISWYDGSTSYADSVKG	47 - 63	17
	Contact	FLAAISWYDGSTS-------	44 - 56	13
	IMGT	----ISWYDGST--------	48 - 55	8
HFR3	Chothia	TSYADSVKGRFTISRVNAKNTVDLQMNSLKSEDTAVYYCAG	55 - 95	41
	AbM	--YADSVKGRFTISRVNAKNTVDLQMNSLKSEDTAVYYCAG	57 - 95	39
	Kabat	---------RFTISRVNAKNTVDLQMNSLKSEDTAVYYCAG	64 - 95	32
	Contact	--YADSVKGRFTISRVNAKNTVDLQMNSLKSEDTAVYYC--	57 - 93	37
	IMGT	-SYADSVKGRFTISRVNAKNTVDLQMNSLKSEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DRGLTAVASSWRY	96 - 108	13
	AbM	--DRGLTAVASSWRY	96 - 108	13
	Kabat	--DRGLTAVASSWRY	96 - 108	13
	Contact	AGDRGLTAVASSWR-	94 - 107	14
	IMGT	AGDRGLTAVASSWRY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55273.1
Source	abYsis-EMBL-IG AM180278 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M79
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQAGGSLRLSCVVSGRIFNNHYMGWFRQAPGKEREFLAAISWYDGSTSYADS
VKGRFTISRVNAKNTVDLQMNSLKSEDTAVYYCAGDRGLTAVASSWRYWGQGTQVT

DNA Sequence:

ctgcagcagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgta
gtctctggacgcatcttcaataaccattacatgggctggttccgccaggctccagggaag
gagcgtgagtttttagcggctattagctggtatgatggtagcacatcgtatgcagactcc
gtgaagggccgattcaccatctccagggtgaacgccaagaacacggtggatctgcaaatg
aacagcctgaaatccgaggacacggccgtttattactgtgcaggagatcgtggtttaacg
gcagtagcaagttcctggaggtactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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