abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGRTFH	1 - 27	27
CDR-H1	NLYMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AISWYDGSPSYADSVKG	47 - 63	17
HFR3	RFTISRDNAKNTVELQMNSLKSEDTAVYFCAG	64 - 95	32
CDR-H3	DRGLTAVASSWRY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGRTFH	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGRTF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRTFHNL---	23 - 29	7
	AbM	GRTFHNLYMG	23 - 32	10
	Kabat	-----NLYMG	28 - 32	5
	Contact	----HNLYMG	27 - 32	6
	IMGT	GRTFHNLY--	23 - 30	8
HFR2	Chothia	YMGWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWYDGS---------	49 - 54	6
	AbM	---AISWYDGSPS-------	47 - 56	10
	Kabat	---AISWYDGSPSYADSVKG	47 - 63	17
	Contact	FVAAISWYDGSPS-------	44 - 56	13
	IMGT	----ISWYDGSP--------	48 - 55	8
HFR3	Chothia	PSYADSVKGRFTISRDNAKNTVELQMNSLKSEDTAVYFCAG	55 - 95	41
	AbM	--YADSVKGRFTISRDNAKNTVELQMNSLKSEDTAVYFCAG	57 - 95	39
	Kabat	---------RFTISRDNAKNTVELQMNSLKSEDTAVYFCAG	64 - 95	32
	Contact	--YADSVKGRFTISRDNAKNTVELQMNSLKSEDTAVYFC--	57 - 93	37
	IMGT	-SYADSVKGRFTISRDNAKNTVELQMNSLKSEDTAVYFC--	56 - 93	38
CDR-H3	Chothia	--DRGLTAVASSWRY	96 - 108	13
	AbM	--DRGLTAVASSWRY	96 - 108	13
	Kabat	--DRGLTAVASSWRY	96 - 108	13
	Contact	AGDRGLTAVASSWR-	94 - 107	14
	IMGT	AGDRGLTAVASSWRY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55275.1
Source	abYsis-EMBL-IG AM180280 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M84
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGRTFHNLYMGWFRQAPGKEREFVAAISWYDGSPSYADS
VKGRFTISRDNAKNTVELQMNSLKSEDTAVYFCAGDRGLTAVASSWRYWGQGTQVT

DNA Sequence:

ctgcaggagtcagggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcaccttccataacctttacatgggctggttccgccaggctccagggaaa
gagcgtgagtttgtagcagctattagctggtatgatggtagcccatcgtatgcagactcc
gtgaagggccgattcaccatctccagagacaacgccaagaacacggtggagctgcaaatg
aacagcctgaaatctgaggacacggccgtttacttctgtgcaggagatcgtggtttgacg
gctgtagcaagttcctggaggtactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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