abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQAGGSLRLSCAASRLIFN	1 - 27	27
CDR-H1	NHYMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AISWYDESTSYANSVKG	47 - 63	17
HFR3	RFTISRDNAKNTVDLQMNSLKSEDTAVYYCTG	64 - 95	32
CDR-H3	DRGLTAVASSWRY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQQSGGGLVQAGGSLRLSCAASRLIFN	1 - 27	27
	Contact	LQQSGGGLVQAGGSLRLSCAASRLIF-	1 - 26	26
	IMGT	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	RLIFNNH---	23 - 29	7
	AbM	RLIFNNHYMG	23 - 32	10
	Kabat	-----NHYMG	28 - 32	5
	Contact	----NNHYMG	27 - 32	6
	IMGT	RLIFNNHY--	23 - 30	8
HFR2	Chothia	YMGWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWYDES---------	49 - 54	6
	AbM	---AISWYDESTS-------	47 - 56	10
	Kabat	---AISWYDESTSYANSVKG	47 - 63	17
	Contact	FVAAISWYDESTS-------	44 - 56	13
	IMGT	----ISWYDEST--------	48 - 55	8
HFR3	Chothia	TSYANSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCTG	55 - 95	41
	AbM	--YANSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCTG	57 - 95	39
	Kabat	---------RFTISRDNAKNTVDLQMNSLKSEDTAVYYCTG	64 - 95	32
	Contact	--YANSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYC--	57 - 93	37
	IMGT	-SYANSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DRGLTAVASSWRY	96 - 108	13
	AbM	--DRGLTAVASSWRY	96 - 108	13
	Kabat	--DRGLTAVASSWRY	96 - 108	13
	Contact	TGDRGLTAVASSWR-	94 - 107	14
	IMGT	TGDRGLTAVASSWRY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55276.1
Source	abYsis-EMBL-IG AM180281 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M85
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQAGGSLRLSCAASRLIFNNHYMGWFRQAPGKEREFVAAISWYDESTSYANS
VKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCTGDRGLTAVASSWRYWGQGTQVT

DNA Sequence:

ctgcagcagtcagggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctcgactcatctttaataatcattacatgggctggttccgccaggctccagggaag
gagcgtgagtttgtagcagctattagctggtatgatgagagcacatcgtatgcaaactcc
gtgaagggccgattcaccatctccagagacaacgccaaaaacacggtggatctgcaaatg
aacagtctgaaatctgaggacacggccgtttattactgtacaggagatcgtggtttgacg
gcagtcgcaagttcctggagatactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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