abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQAGGSLRLSCAASGRAFQ	1 - 27	27
CDR-H1	YYYMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AISWYDGSTSYADSVKG	47 - 63	17
HFR3	RFTISRDNAKNTVDLQMNSLKSEDTAVYYCAG	64 - 95	32
CDR-H3	DRGLTAVASSWRY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQQSGGGLVQAGGSLRLSCAASGRAFQ	1 - 27	27
	Contact	LQQSGGGLVQAGGSLRLSCAASGRAF-	1 - 26	26
	IMGT	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRAFQYY---	23 - 29	7
	AbM	GRAFQYYYMG	23 - 32	10
	Kabat	-----YYYMG	28 - 32	5
	Contact	----QYYYMG	27 - 32	6
	IMGT	GRAFQYYY--	23 - 30	8
HFR2	Chothia	YMGWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWYDGS---------	49 - 54	6
	AbM	---AISWYDGSTS-------	47 - 56	10
	Kabat	---AISWYDGSTSYADSVKG	47 - 63	17
	Contact	FVAAISWYDGSTS-------	44 - 56	13
	IMGT	----ISWYDGST--------	48 - 55	8
HFR3	Chothia	TSYADSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCAG	55 - 95	41
	AbM	--YADSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCAG	57 - 95	39
	Kabat	---------RFTISRDNAKNTVDLQMNSLKSEDTAVYYCAG	64 - 95	32
	Contact	--YADSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYC--	57 - 93	37
	IMGT	-SYADSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DRGLTAVASSWRY	96 - 108	13
	AbM	--DRGLTAVASSWRY	96 - 108	13
	Kabat	--DRGLTAVASSWRY	96 - 108	13
	Contact	AGDRGLTAVASSWR-	94 - 107	14
	IMGT	AGDRGLTAVASSWRY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55317.1
Source	abYsis-EMBL-IG AM180284 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M116
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQAGGSLRLSCAASGRAFQYYYMGWFRQAPGKEREFVAAISWYDGSTSYADS
VKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCAGDRGLTAVASSWRYWGQGTQVT

DNA Sequence:

ctgcagcagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcgccttccagtactattacatgggatggttccgccaggctccaggaaag
gagcgtgagtttgtagcagctattagttggtatgatggtagcacatcgtatgcagactcc
gtgaagggccgattcaccatctccagagacaacgccaagaacacggtagatctgcaaatg
aacagcctgaaatctgaggacacggccgtttattactgtgcaggagatcgtggtttgacg
gcagtagcaagttcctggaggtactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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