abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGMVQAGGSLRLSCAASQLIFN	1 - 27	27
CDR-H1	NHYLA	28 - 32	5
HFR2	WFRQAPGKERMFVA	33 - 46	14
CDR-H2	AISWYDGSTSYTNSVKG	47 - 63	17
HFR3	RFTISRDNAKNTVDLQMNSLKSEDTAVYYCAG	64 - 95	32
CDR-H3	DRGLTSVASSWRY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGMVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQQSGGGMVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQQSGGGMVQAGGSLRLSCAASQLIFN	1 - 27	27
	Contact	LQQSGGGMVQAGGSLRLSCAASQLIF-	1 - 26	26
	IMGT	LQQSGGGMVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	QLIFNNH---	23 - 29	7
	AbM	QLIFNNHYLA	23 - 32	10
	Kabat	-----NHYLA	28 - 32	5
	Contact	----NNHYLA	27 - 32	6
	IMGT	QLIFNNHY--	23 - 30	8
HFR2	Chothia	YLAWFRQAPGKERMFVAAI	30 - 48	19
	AbM	---WFRQAPGKERMFVA--	33 - 46	14
	Kabat	---WFRQAPGKERMFVA--	33 - 46	14
	Contact	---WFRQAPGKERM-----	33 - 43	11
	IMGT	-LAWFRQAPGKERMFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWYDGS---------	49 - 54	6
	AbM	---AISWYDGSTS-------	47 - 56	10
	Kabat	---AISWYDGSTSYTNSVKG	47 - 63	17
	Contact	FVAAISWYDGSTS-------	44 - 56	13
	IMGT	----ISWYDGST--------	48 - 55	8
HFR3	Chothia	TSYTNSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCAG	55 - 95	41
	AbM	--YTNSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCAG	57 - 95	39
	Kabat	---------RFTISRDNAKNTVDLQMNSLKSEDTAVYYCAG	64 - 95	32
	Contact	--YTNSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYC--	57 - 93	37
	IMGT	-SYTNSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DRGLTSVASSWRY	96 - 108	13
	AbM	--DRGLTSVASSWRY	96 - 108	13
	Kabat	--DRGLTSVASSWRY	96 - 108	13
	Contact	AGDRGLTSVASSWR-	94 - 107	14
	IMGT	AGDRGLTSVASSWRY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55279.1
Source	abYsis-EMBL-IG AM180285 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M123
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGMVQAGGSLRLSCAASQLIFNNHYLAWFRQAPGKERMFVAAISWYDGSTSYTNS
VKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCAGDRGLTSVASSWRYWGQGTQVT

DNA Sequence:

ctgcagcagtcagggggaggaatggtgcaggctgggggctctctgagactctcctgtgca
gcctctcaactcatcttcaataatcattacttggcatggttccgccaggctccagggaag
gagcgtatgtttgtagcagctattagttggtatgatggtagcacatcgtatacaaactcc
gtgaagggccgattcaccatctccagagacaacgccaaaaacacggtggatctgcaaatg
aacagcctgaaatctgaggacacggccgtttattactgtgcaggagatcgtggtttgacg
tccgtagcaagttcctggagrtactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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