abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQAGGSLRLSCAASGRAFN	1 - 27	27
CDR-H1	YYYMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AISWYDASTSYADSVKG	47 - 63	17
HFR3	RFTISRDNAKNTVDLQMNSLKSEDTAVYYCVG	64 - 95	32
CDR-H3	DRGLTDVPSSWRY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQQSGGGLVQAGGSLRLSCAASGRAFN	1 - 27	27
	Contact	LQQSGGGLVQAGGSLRLSCAASGRAF-	1 - 26	26
	IMGT	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRAFNYY---	23 - 29	7
	AbM	GRAFNYYYMG	23 - 32	10
	Kabat	-----YYYMG	28 - 32	5
	Contact	----NYYYMG	27 - 32	6
	IMGT	GRAFNYYY--	23 - 30	8
HFR2	Chothia	YMGWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWYDAS---------	49 - 54	6
	AbM	---AISWYDASTS-------	47 - 56	10
	Kabat	---AISWYDASTSYADSVKG	47 - 63	17
	Contact	FVAAISWYDASTS-------	44 - 56	13
	IMGT	----ISWYDAST--------	48 - 55	8
HFR3	Chothia	TSYADSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCVG	55 - 95	41
	AbM	--YADSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCVG	57 - 95	39
	Kabat	---------RFTISRDNAKNTVDLQMNSLKSEDTAVYYCVG	64 - 95	32
	Contact	--YADSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYC--	57 - 93	37
	IMGT	-SYADSVKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DRGLTDVPSSWRY	96 - 108	13
	AbM	--DRGLTDVPSSWRY	96 - 108	13
	Kabat	--DRGLTDVPSSWRY	96 - 108	13
	Contact	VGDRGLTDVPSSWR-	94 - 107	14
	IMGT	VGDRGLTDVPSSWRY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55280.1
Source	abYsis-EMBL-IG AM180286 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M126
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQAGGSLRLSCAASGRAFNYYYMGWFRQAPGKEREFVAAISWYDASTSYADS
VKGRFTISRDNAKNTVDLQMNSLKSEDTAVYYCVGDRGLTDVPSSWRYWGQGTQVT

DNA Sequence:

ctgcagcagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcgccttcaattactattacatgggatggttccgccaggctccaggaaag
gagcgtgagtttgtagcagctattagctggtatgatgctagcacatcgtatgcagactcc
gtgaagggccgattcaccatctccagagacaacgccaagaacacggtagatctgcaaatg
aacagcctgaaatctgaggacacggccgtttattactgtgtaggagatcgtggtttgacg
gatgtaccaagttcctggaggtactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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