abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQAGGSLRLSCQASRLSFN	1 - 27	27
CDR-H1	HYYMG	28 - 32	5
HFR2	WFRQAPGKNREFVA	33 - 46	14
CDR-H2	AISWYDHSTSYADSVKG	47 - 63	17
HFR3	RFTISRDNAKNTVDLQMNALKSEDTAVYYCVG	64 - 95	32
CDR-H3	DRGLTAVDSSWRY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQAGGSLRLSCQAS-----	1 - 22	22
	AbM	LQQSGGGLVQAGGSLRLSCQAS-----	1 - 22	22
	Kabat	LQQSGGGLVQAGGSLRLSCQASRLSFN	1 - 27	27
	Contact	LQQSGGGLVQAGGSLRLSCQASRLSF-	1 - 26	26
	IMGT	LQQSGGGLVQAGGSLRLSCQAS-----	1 - 22	22
CDR-H1	Chothia	RLSFNHY---	23 - 29	7
	AbM	RLSFNHYYMG	23 - 32	10
	Kabat	-----HYYMG	28 - 32	5
	Contact	----NHYYMG	27 - 32	6
	IMGT	RLSFNHYY--	23 - 30	8
HFR2	Chothia	YMGWFRQAPGKNREFVAAI	30 - 48	19
	AbM	---WFRQAPGKNREFVA--	33 - 46	14
	Kabat	---WFRQAPGKNREFVA--	33 - 46	14
	Contact	---WFRQAPGKNRE-----	33 - 43	11
	IMGT	-MGWFRQAPGKNREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWYDHS---------	49 - 54	6
	AbM	---AISWYDHSTS-------	47 - 56	10
	Kabat	---AISWYDHSTSYADSVKG	47 - 63	17
	Contact	FVAAISWYDHSTS-------	44 - 56	13
	IMGT	----ISWYDHST--------	48 - 55	8
HFR3	Chothia	TSYADSVKGRFTISRDNAKNTVDLQMNALKSEDTAVYYCVG	55 - 95	41
	AbM	--YADSVKGRFTISRDNAKNTVDLQMNALKSEDTAVYYCVG	57 - 95	39
	Kabat	---------RFTISRDNAKNTVDLQMNALKSEDTAVYYCVG	64 - 95	32
	Contact	--YADSVKGRFTISRDNAKNTVDLQMNALKSEDTAVYYC--	57 - 93	37
	IMGT	-SYADSVKGRFTISRDNAKNTVDLQMNALKSEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DRGLTAVDSSWRY	96 - 108	13
	AbM	--DRGLTAVDSSWRY	96 - 108	13
	Kabat	--DRGLTAVDSSWRY	96 - 108	13
	Contact	VGDRGLTAVDSSWR-	94 - 107	14
	IMGT	VGDRGLTAVDSSWRY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55281.1
Source	abYsis-EMBL-IG AM180287 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M163
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQAGGSLRLSCQASRLSFNHYYMGWFRQAPGKNREFVAAISWYDHSTSYADS
VKGRFTISRDNAKNTVDLQMNALKSEDTAVYYCVGDRGLTAVDSSWRYWGQGTQVT

DNA Sequence:

ctgcagcagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtcaa
gcctctcgactctccttcaatcactattacatgggctggttccgccaggctccagggaag
aaccgtgagtttgtagcagctattagttggtatgatcatagcacatcgtatgcagactcc
gtgaagggccggttcaccatctccagagacaacgccaaaaacacggtggatctgcaaatg
aacgccctgaaatctgaggacacggccgtttattactgtgtaggagatcgtggtttgacg
gctgtagacagttcctggagatactggggacaggggacccaggtcacc

Data Source:

Alignment settings:

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