abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQPEGSLRLSCVASGTIFS	1 - 27	27
CDR-H1	INDISINHMG	28 - 37	10
HFR2	WYRQAPGKERELVA	38 - 51	14
CDR-H2	AITADGTSAYEDSVKG	52 - 67	16
HFR3	RFTISRDDAKKLVYLQMNNLKPEDTAVYYCNG	68 - 99	32
CDR-H3	LRASNAGWEPRFGT	100 - 113	14
HFR4	WGQGTQVT	114 - 121	8
			121

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQPEGSLRLSCVAS-----	1 - 22	22
	AbM	LQESGGGLVQPEGSLRLSCVAS-----	1 - 22	22
	Kabat	LQESGGGLVQPEGSLRLSCVASGTIFS	1 - 27	27
	Contact	LQESGGGLVQPEGSLRLSCVASGTIF-	1 - 26	26
	IMGT	LQESGGGLVQPEGSLRLSCVAS-----	1 - 22	22
CDR-H1	Chothia	GTIFSINDISIN---	23 - 34	12
	AbM	GTIFSINDISINHMG	23 - 37	15
	Kabat	-----INDISINHMG	28 - 37	10
	Contact	----SINDISINHMG	27 - 37	11
	IMGT	GTIFSINDISINH--	23 - 35	13
HFR2	Chothia	HMGWYRQAPGKERELVAAI	35 - 53	19
	AbM	---WYRQAPGKERELVA--	38 - 51	14
	Kabat	---WYRQAPGKERELVA--	38 - 51	14
	Contact	---WYRQAPGKERE-----	38 - 48	11
	IMGT	-MGWYRQAPGKERELVAA-	36 - 52	17
CDR-H2	Chothia	-----TADGT---------	54 - 58	5
	AbM	---AITADGTSA-------	52 - 60	9
	Kabat	---AITADGTSAYEDSVKG	52 - 67	16
	Contact	LVAAITADGTSA-------	49 - 60	12
	IMGT	----ITADGTS--------	53 - 59	7
HFR3	Chothia	SAYEDSVKGRFTISRDDAKKLVYLQMNNLKPEDTAVYYCNG	59 - 99	41
	AbM	--YEDSVKGRFTISRDDAKKLVYLQMNNLKPEDTAVYYCNG	61 - 99	39
	Kabat	---------RFTISRDDAKKLVYLQMNNLKPEDTAVYYCNG	68 - 99	32
	Contact	--YEDSVKGRFTISRDDAKKLVYLQMNNLKPEDTAVYYC--	61 - 97	37
	IMGT	-AYEDSVKGRFTISRDDAKKLVYLQMNNLKPEDTAVYYC--	60 - 97	38
CDR-H3	Chothia	--LRASNAGWEPRFGT	100 - 113	14
	AbM	--LRASNAGWEPRFGT	100 - 113	14
	Kabat	--LRASNAGWEPRFGT	100 - 113	14
	Contact	NGLRASNAGWEPRFG-	98 - 112	15
	IMGT	NGLRASNAGWEPRFGT	98 - 113	16
HFR4	Chothia	-WGQGTQVT	114 - 121	8
	AbM	-WGQGTQVT	114 - 121	8
	Kabat	-WGQGTQVT	114 - 121	8
	Contact	TWGQGTQVT	113 - 121	9
	IMGT	-WGQGTQVT	114 - 121	8

Accession & Annotations

Accession	CAJ55282.1
Source	abYsis-EMBL-IG AM180288 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M188
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQPEGSLRLSCVASGTIFSINDISINHMGWYRQAPGKERELVAAITADGTSA
YEDSVKGRFTISRDDAKKLVYLQMNNLKPEDTAVYYCNGLRASNAGWEPRFGTWGQGTQV
T

DNA Sequence:

ctgcaggagtctgggggaggcttggtgcagcctgaggggtctctgagactctcctgtgta
gcctctggaacgatcttcagtatcaatgacatcagtatcaatcacatgggctggtaccgc
caggctccagggaaggaacgcgagttggtcgcggctatcactgctgatggcacatcagcc
tatgaagactccgtgaagggccgattcaccatctccagagacgacgccaagaaattggtt
tatctgcaaatgaacaacctgaaacccgaggacacggccgtctattactgtaatggtcta
agggcctcgaatgcgggttgggagccgcgctttggtacttggggccaggggacccaggtc
acc

Data Source:

Alignment settings:

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