abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQPGGSLRLSCVASGTIFS	1 - 27	27
CDR-H1	INDISINHMG	28 - 37	10
HFR2	WYRQAPGKERELVA	38 - 51	14
CDR-H2	AITADGTSAYEDSVKG	52 - 67	16
HFR3	RFTISRDDAKKMVYLQMNSLKPEDTAVYYCNG	68 - 99	32
CDR-H3	LRASNAGWEPRFGT	100 - 113	14
HFR4	WGQGTQVS	114 - 121	8
			121

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQPGGSLRLSCVAS-----	1 - 22	22
	AbM	LQESGGGLVQPGGSLRLSCVAS-----	1 - 22	22
	Kabat	LQESGGGLVQPGGSLRLSCVASGTIFS	1 - 27	27
	Contact	LQESGGGLVQPGGSLRLSCVASGTIF-	1 - 26	26
	IMGT	LQESGGGLVQPGGSLRLSCVAS-----	1 - 22	22
CDR-H1	Chothia	GTIFSINDISIN---	23 - 34	12
	AbM	GTIFSINDISINHMG	23 - 37	15
	Kabat	-----INDISINHMG	28 - 37	10
	Contact	----SINDISINHMG	27 - 37	11
	IMGT	GTIFSINDISINH--	23 - 35	13
HFR2	Chothia	HMGWYRQAPGKERELVAAI	35 - 53	19
	AbM	---WYRQAPGKERELVA--	38 - 51	14
	Kabat	---WYRQAPGKERELVA--	38 - 51	14
	Contact	---WYRQAPGKERE-----	38 - 48	11
	IMGT	-MGWYRQAPGKERELVAA-	36 - 52	17
CDR-H2	Chothia	-----TADGT---------	54 - 58	5
	AbM	---AITADGTSA-------	52 - 60	9
	Kabat	---AITADGTSAYEDSVKG	52 - 67	16
	Contact	LVAAITADGTSA-------	49 - 60	12
	IMGT	----ITADGTS--------	53 - 59	7
HFR3	Chothia	SAYEDSVKGRFTISRDDAKKMVYLQMNSLKPEDTAVYYCNG	59 - 99	41
	AbM	--YEDSVKGRFTISRDDAKKMVYLQMNSLKPEDTAVYYCNG	61 - 99	39
	Kabat	---------RFTISRDDAKKMVYLQMNSLKPEDTAVYYCNG	68 - 99	32
	Contact	--YEDSVKGRFTISRDDAKKMVYLQMNSLKPEDTAVYYC--	61 - 97	37
	IMGT	-AYEDSVKGRFTISRDDAKKMVYLQMNSLKPEDTAVYYC--	60 - 97	38
CDR-H3	Chothia	--LRASNAGWEPRFGT	100 - 113	14
	AbM	--LRASNAGWEPRFGT	100 - 113	14
	Kabat	--LRASNAGWEPRFGT	100 - 113	14
	Contact	NGLRASNAGWEPRFG-	98 - 112	15
	IMGT	NGLRASNAGWEPRFGT	98 - 113	16
HFR4	Chothia	-WGQGTQVS	114 - 121	8
	AbM	-WGQGTQVS	114 - 121	8
	Kabat	-WGQGTQVS	114 - 121	8
	Contact	TWGQGTQVS	113 - 121	9
	IMGT	-WGQGTQVS	114 - 121	8

Accession & Annotations

Accession	CAJ55283.1
Source	abYsis-EMBL-IG AM180289 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M195
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQPGGSLRLSCVASGTIFSINDISINHMGWYRQAPGKERELVAAITADGTSA
YEDSVKGRFTISRDDAKKMVYLQMNSLKPEDTAVYYCNGLRASNAGWEPRFGTWGQGTQV
S

DNA Sequence:

ctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactctcctgtgta
gcctctggaacgatcttcagtatcaatgacatcagtatcaatcacatgggctggtaccgc
caggctccagggaaggaacgcgagttggtcgcggctatcactgctgatggtacatcagcc
tatgaagactccgtgaagggccgattcaccatctccagagacgacgccaaaaagatggtg
tatctgcaaatgaacagcctgaaacccgaggacacggccgtctattactgtaatggtcta
agggcctcgaatgcgggttgggagccccgctttggtacttggggccaggggacccaggtc
tcc

Data Source:

Alignment settings:

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