abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGRTFS	1 - 27	27
CDR-H1	SYAMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	RINWSGGSTYYADSVKG	47 - 63	17
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAVYYCTA	64 - 95	32
CDR-H3	GFALPPSDY	96 - 104	9
HFR4	WGQGTRVT	105 - 112	8
			112

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGRTFS	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGRTF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRTFSSY---	23 - 29	7
	AbM	GRTFSSYAMG	23 - 32	10
	Kabat	-----SYAMG	28 - 32	5
	Contact	----SSYAMG	27 - 32	6
	IMGT	GRTFSSYA--	23 - 30	8
HFR2	Chothia	AMGWFRQAPGKEREFVARI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAR-	31 - 47	17
CDR-H2	Chothia	-----NWSGGS---------	49 - 54	6
	AbM	---RINWSGGSTY-------	47 - 56	10
	Kabat	---RINWSGGSTYYADSVKG	47 - 63	17
	Contact	FVARINWSGGSTY-------	44 - 56	13
	IMGT	----INWSGGST--------	48 - 55	8
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCTA	55 - 95	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCTA	57 - 95	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAVYYCTA	64 - 95	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	57 - 93	37
	IMGT	-YYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--GFALPPSDY	96 - 104	9
	AbM	--GFALPPSDY	96 - 104	9
	Kabat	--GFALPPSDY	96 - 104	9
	Contact	TAGFALPPSD-	94 - 103	10
	IMGT	TAGFALPPSDY	94 - 104	11
HFR4	Chothia	-WGQGTRVT	105 - 112	8
	AbM	-WGQGTRVT	105 - 112	8
	Kabat	-WGQGTRVT	105 - 112	8
	Contact	YWGQGTRVT	104 - 112	9
	IMGT	-WGQGTRVT	105 - 112	8

Accession & Annotations

Accession	CAJ55284.1
Source	abYsis-EMBL-IG AM180290 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M208
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGRTFSSYAMGWFRQAPGKEREFVARINWSGGSTYYADS
VKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCTAGFALPPSDYWGQGTRVT

DNA Sequence:

ctgcaggagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcaccttcagtagctatgccatgggctggttccgccaggctccagggaag
gagcgtgagtttgtagcacgtattaactggagtggtggtagcacatactatgcagactcc
gtgaagggccgattcaccatctccagagacaacgccaagaacacggtgtatctgcaaatg
aacagcctgaaacctgaggacacggccgtttattactgtacagcaggtttcgcgctacca
cccagtgactactggggccaggggacccgggtcacc

Data Source:

Alignment settings:

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