abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGRTFS	1 - 27	27
CDR-H1	SNAMG	28 - 32	5
HFR2	WFRQAPGKEREFVG	33 - 46	14
CDR-H2	AISFGGHSTNYRDSVEG	47 - 63	17
HFR3	RFTISRDDVKNTVYLQMNSLKPEDTAVYYCAA	64 - 95	32
CDR-H3	STGSQATMNLRSYTY	96 - 110	15
HFR4	WGQGTQVT	111 - 118	8
			118

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGRTFS	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGRTF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRTFSSN---	23 - 29	7
	AbM	GRTFSSNAMG	23 - 32	10
	Kabat	-----SNAMG	28 - 32	5
	Contact	----SSNAMG	27 - 32	6
	IMGT	GRTFSSNA--	23 - 30	8
HFR2	Chothia	AMGWFRQAPGKEREFVGAI	30 - 48	19
	AbM	---WFRQAPGKEREFVG--	33 - 46	14
	Kabat	---WFRQAPGKEREFVG--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVGA-	31 - 47	17
CDR-H2	Chothia	-----SFGGHS---------	49 - 54	6
	AbM	---AISFGGHSTN-------	47 - 56	10
	Kabat	---AISFGGHSTNYRDSVEG	47 - 63	17
	Contact	FVGAISFGGHSTN-------	44 - 56	13
	IMGT	----ISFGGHST--------	48 - 55	8
HFR3	Chothia	TNYRDSVEGRFTISRDDVKNTVYLQMNSLKPEDTAVYYCAA	55 - 95	41
	AbM	--YRDSVEGRFTISRDDVKNTVYLQMNSLKPEDTAVYYCAA	57 - 95	39
	Kabat	---------RFTISRDDVKNTVYLQMNSLKPEDTAVYYCAA	64 - 95	32
	Contact	--YRDSVEGRFTISRDDVKNTVYLQMNSLKPEDTAVYYC--	57 - 93	37
	IMGT	-NYRDSVEGRFTISRDDVKNTVYLQMNSLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--STGSQATMNLRSYTY	96 - 110	15
	AbM	--STGSQATMNLRSYTY	96 - 110	15
	Kabat	--STGSQATMNLRSYTY	96 - 110	15
	Contact	AASTGSQATMNLRSYT-	94 - 109	16
	IMGT	AASTGSQATMNLRSYTY	94 - 110	17
HFR4	Chothia	-WGQGTQVT	111 - 118	8
	AbM	-WGQGTQVT	111 - 118	8
	Kabat	-WGQGTQVT	111 - 118	8
	Contact	YWGQGTQVT	110 - 118	9
	IMGT	-WGQGTQVT	111 - 118	8

Accession & Annotations

Accession	CAJ55285.1
Source	abYsis-EMBL-IG AM180291 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M4
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGRTFSSNAMGWFRQAPGKEREFVGAISFGGHSTNYRDS
VEGRFTISRDDVKNTVYLQMNSLKPEDTAVYYCAASTGSQATMNLRSYTYWGQGTQVT

DNA Sequence:

ctgcaggagtcagggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcaccttcagtagtaatgccatgggctggttccgccaggctccagggaag
gagcgtgaatttgtaggtgccattagtttcggtggtcattcgacaaactatagagactcc
gtggagggccgattcaccatctccagagacgacgtcaagaatacggtgtatttgcaaatg
aacagcctgaaacctgaggacacggccgtttattactgtgcagcgtccacagggtctcaa
gcaacaatgaatctccggagttatacctactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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