abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQPGGSLTLSCAASGFSFS	1 - 27	27
CDR-H1	SYWMY	28 - 32	5
HFR2	WVRQAPGKGLERVS	33 - 46	14
CDR-H2	QISARSSVVDYADSVKG	47 - 63	17
HFR3	RFTISRDNAKNTLYLQMNSLESEDTAVYYCAR	64 - 95	32
CDR-H3	DCTTGGGLVSCNV	96 - 108	13
HFR4	RGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQPGGSLTLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQPGGSLTLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQPGGSLTLSCAASGFSFS	1 - 27	27
	Contact	LQESGGGLVQPGGSLTLSCAASGFSF-	1 - 26	26
	IMGT	LQESGGGLVQPGGSLTLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GFSFSSY---	23 - 29	7
	AbM	GFSFSSYWMY	23 - 32	10
	Kabat	-----SYWMY	28 - 32	5
	Contact	----SSYWMY	27 - 32	6
	IMGT	GFSFSSYW--	23 - 30	8
HFR2	Chothia	WMYWVRQAPGKGLERVSQI	30 - 48	19
	AbM	---WVRQAPGKGLERVS--	33 - 46	14
	Kabat	---WVRQAPGKGLERVS--	33 - 46	14
	Contact	---WVRQAPGKGLE-----	33 - 43	11
	IMGT	-MYWVRQAPGKGLERVSQ-	31 - 47	17
CDR-H2	Chothia	-----SARSSV---------	49 - 54	6
	AbM	---QISARSSVVD-------	47 - 56	10
	Kabat	---QISARSSVVDYADSVKG	47 - 63	17
	Contact	RVSQISARSSVVD-------	44 - 56	13
	IMGT	----ISARSSVV--------	48 - 55	8
HFR3	Chothia	VDYADSVKGRFTISRDNAKNTLYLQMNSLESEDTAVYYCAR	55 - 95	41
	AbM	--YADSVKGRFTISRDNAKNTLYLQMNSLESEDTAVYYCAR	57 - 95	39
	Kabat	---------RFTISRDNAKNTLYLQMNSLESEDTAVYYCAR	64 - 95	32
	Contact	--YADSVKGRFTISRDNAKNTLYLQMNSLESEDTAVYYC--	57 - 93	37
	IMGT	-DYADSVKGRFTISRDNAKNTLYLQMNSLESEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DCTTGGGLVSCNV	96 - 108	13
	AbM	--DCTTGGGLVSCNV	96 - 108	13
	Kabat	--DCTTGGGLVSCNV	96 - 108	13
	Contact	ARDCTTGGGLVSCN-	94 - 107	14
	IMGT	ARDCTTGGGLVSCNV	94 - 108	15
HFR4	Chothia	-RGQGTQVT	109 - 116	8
	AbM	-RGQGTQVT	109 - 116	8
	Kabat	-RGQGTQVT	109 - 116	8
	Contact	VRGQGTQVT	108 - 116	9
	IMGT	-RGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55288.1
Source	abYsis-EMBL-IG AM180294 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M1
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQPGGSLTLSCAASGFSFSSYWMYWVRQAPGKGLERVSQISARSSVVDYADS
VKGRFTISRDNAKNTLYLQMNSLESEDTAVYYCARDCTTGGGLVSCNVRGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggcttggtgcagcctggggggtctctgaccctctcctgtgca
gcctctggattcagcttcagtagttattggatgtattgggtccgtcaggctccaggaaag
gggctcgagcgggtctcacagattagcgcgcgtagtagtgtagtggactatgctgactcc
gtgaagggccgattcaccatctccagagacaacgccaagaacacgctgtatctgcaaatg
aacagtctggaatctgaggacacggccgtatattactgtgcaagagattgcacaacaggc
ggtggtctagtctcatgtaacgtccggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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