abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQAGASLRLSCTAPGRTLS	1 - 27	27
CDR-H1	TYPMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AVDWRGSSTDTGDSVKG	47 - 63	17
HFR3	RFTTFKDNASLYLQMKGLKPEDSAVYYCAA	64 - 93	30
CDR-H3	GRSYEARSFSANDYAY	94 - 109	16
HFR4	WGQGTQVT	110 - 117	8
			117

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQAGASLRLSCTAP-----	1 - 22	22
	AbM	LQQSGGGLVQAGASLRLSCTAP-----	1 - 22	22
	Kabat	LQQSGGGLVQAGASLRLSCTAPGRTLS	1 - 27	27
	Contact	LQQSGGGLVQAGASLRLSCTAPGRTL-	1 - 26	26
	IMGT	LQQSGGGLVQAGASLRLSCTAP-----	1 - 22	22
CDR-H1	Chothia	GRTLSTY---	23 - 29	7
	AbM	GRTLSTYPMG	23 - 32	10
	Kabat	-----TYPMG	28 - 32	5
	Contact	----STYPMG	27 - 32	6
	IMGT	GRTLSTYP--	23 - 30	8
HFR2	Chothia	PMGWFRQAPGKEREFVAAV	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----DWRGSS---------	49 - 54	6
	AbM	---AVDWRGSSTD-------	47 - 56	10
	Kabat	---AVDWRGSSTDTGDSVKG	47 - 63	17
	Contact	FVAAVDWRGSSTD-------	44 - 56	13
	IMGT	----VDWRGSST--------	48 - 55	8
HFR3	Chothia	TDTGDSVKGRFTTFKDNASLYLQMKGLKPEDSAVYYCAA	55 - 93	39
	AbM	--TGDSVKGRFTTFKDNASLYLQMKGLKPEDSAVYYCAA	57 - 93	37
	Kabat	---------RFTTFKDNASLYLQMKGLKPEDSAVYYCAA	64 - 93	30
	Contact	--TGDSVKGRFTTFKDNASLYLQMKGLKPEDSAVYYC--	57 - 91	35
	IMGT	-DTGDSVKGRFTTFKDNASLYLQMKGLKPEDSAVYYC--	56 - 91	36
CDR-H3	Chothia	--GRSYEARSFSANDYAY	94 - 109	16
	AbM	--GRSYEARSFSANDYAY	94 - 109	16
	Kabat	--GRSYEARSFSANDYAY	94 - 109	16
	Contact	AAGRSYEARSFSANDYA-	92 - 108	17
	IMGT	AAGRSYEARSFSANDYAY	92 - 109	18
HFR4	Chothia	-WGQGTQVT	110 - 117	8
	AbM	-WGQGTQVT	110 - 117	8
	Kabat	-WGQGTQVT	110 - 117	8
	Contact	YWGQGTQVT	109 - 117	9
	IMGT	-WGQGTQVT	110 - 117	8

Accession & Annotations

Accession	CAJ55289.1
Source	abYsis-EMBL-IG AM180295 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M2
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQAGASLRLSCTAPGRTLSTYPMGWFRQAPGKEREFVAAVDWRGSSTDTGDS
VKGRFTTFKDNASLYLQMKGLKPEDSAVYYCAAGRSYEARSFSANDYAYWGQGTQVT

DNA Sequence:

ctgcagcagtcagggggaggattggtgcaggctggggcctctctgagactctcctgtaca
gcccctggacgcaccttgagtacgtatcccatgggctggttccgccaggccccagggaag
gagcgtgagtttgttgcagctgttgattggcgtggtagcagtacagatactggagactcc
gtgaagggccgattcaccaccttcaaggacaacgccagcttgtatctgcaaatgaaaggc
ctgaaacctgaagactcggccgtttattactgtgcagcaggcagaagttacgaggcgcga
tctttcagtgccaatgactatgcctactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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