abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGGLRLSCAASGITLS	1 - 27	27
CDR-H1	FYGMG	28 - 32	5
HFR2	WFRQAPGGEREFVA	33 - 46	14
CDR-H2	AITSNGDSTYYEDSVKG	47 - 63	17
HFR3	RFTISRDNAKSTVFLQMNRLKPEDTAVYYCGA	64 - 95	32
CDR-H3	AFRLSGSHLFDRLYYVH	96 - 112	17
HFR4	WGQGTQVT	113 - 120	8
			120

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGGLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGGLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGGLRLSCAASGITLS	1 - 27	27
	Contact	LQESGGGLVQAGGGLRLSCAASGITL-	1 - 26	26
	IMGT	LQESGGGLVQAGGGLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GITLSFY---	23 - 29	7
	AbM	GITLSFYGMG	23 - 32	10
	Kabat	-----FYGMG	28 - 32	5
	Contact	----SFYGMG	27 - 32	6
	IMGT	GITLSFYG--	23 - 30	8
HFR2	Chothia	GMGWFRQAPGGEREFVAAI	30 - 48	19
	AbM	---WFRQAPGGEREFVA--	33 - 46	14
	Kabat	---WFRQAPGGEREFVA--	33 - 46	14
	Contact	---WFRQAPGGERE-----	33 - 43	11
	IMGT	-MGWFRQAPGGEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----TSNGDS---------	49 - 54	6
	AbM	---AITSNGDSTY-------	47 - 56	10
	Kabat	---AITSNGDSTYYEDSVKG	47 - 63	17
	Contact	FVAAITSNGDSTY-------	44 - 56	13
	IMGT	----ITSNGDST--------	48 - 55	8
HFR3	Chothia	TYYEDSVKGRFTISRDNAKSTVFLQMNRLKPEDTAVYYCGA	55 - 95	41
	AbM	--YEDSVKGRFTISRDNAKSTVFLQMNRLKPEDTAVYYCGA	57 - 95	39
	Kabat	---------RFTISRDNAKSTVFLQMNRLKPEDTAVYYCGA	64 - 95	32
	Contact	--YEDSVKGRFTISRDNAKSTVFLQMNRLKPEDTAVYYC--	57 - 93	37
	IMGT	-YYEDSVKGRFTISRDNAKSTVFLQMNRLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--AFRLSGSHLFDRLYYVH	96 - 112	17
	AbM	--AFRLSGSHLFDRLYYVH	96 - 112	17
	Kabat	--AFRLSGSHLFDRLYYVH	96 - 112	17
	Contact	GAAFRLSGSHLFDRLYYV-	94 - 111	18
	IMGT	GAAFRLSGSHLFDRLYYVH	94 - 112	19
HFR4	Chothia	-WGQGTQVT	113 - 120	8
	AbM	-WGQGTQVT	113 - 120	8
	Kabat	-WGQGTQVT	113 - 120	8
	Contact	HWGQGTQVT	112 - 120	9
	IMGT	-WGQGTQVT	113 - 120	8

Accession & Annotations

Accession	CAJ55290.1
Source	abYsis-EMBL-IG AM180296 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M7
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGGLRLSCAASGITLSFYGMGWFRQAPGGEREFVAAITSNGDSTYYEDS
VKGRFTISRDNAKSTVFLQMNRLKPEDTAVYYCGAAFRLSGSHLFDRLYYVHWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggattggtgcaggctgggggaggtctgagactctcctgtgca
gcctctggaattaccctcagcttttatggcatgggctggttccgccaggctccaggaggg
gagcgtgagtttgtagcagctattacttccaatggggatagcacgtactatgaagactcc
gtgaagggccgattcaccatctccagggacaacgccaagagcacggtttttctgcaaatg
aacagattgaaacctgaggacacggccgtttactactgtggagccgctttcagattgagt
ggtagtcacttattcgaccgactgtactatgtacattggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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