abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQPGGSLRLSCAASGFTFS	1 - 27	27
CDR-H1	NWVMN	28 - 32	5
HFR2	WVRQAPGKGLEWVA	33 - 46	14
CDR-H2	QIDSGSTYRSYADSVKG	47 - 63	17
HFR3	RFSIDRDNSKNTLYLEMDNLQPADTAVYYCRK	64 - 95	32
CDR-H3	GGGE	96 - 99	4
HFR4	RGQGTQVT	100 - 107	8
			107

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQPGGSLRLSCAASGFTFS	1 - 27	27
	Contact	LQESGGGLVQPGGSLRLSCAASGFTF-	1 - 26	26
	IMGT	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GFTFSNW---	23 - 29	7
	AbM	GFTFSNWVMN	23 - 32	10
	Kabat	-----NWVMN	28 - 32	5
	Contact	----SNWVMN	27 - 32	6
	IMGT	GFTFSNWV--	23 - 30	8
HFR2	Chothia	VMNWVRQAPGKGLEWVAQI	30 - 48	19
	AbM	---WVRQAPGKGLEWVA--	33 - 46	14
	Kabat	---WVRQAPGKGLEWVA--	33 - 46	14
	Contact	---WVRQAPGKGLE-----	33 - 43	11
	IMGT	-MNWVRQAPGKGLEWVAQ-	31 - 47	17
CDR-H2	Chothia	-----DSGSTY---------	49 - 54	6
	AbM	---QIDSGSTYRS-------	47 - 56	10
	Kabat	---QIDSGSTYRSYADSVKG	47 - 63	17
	Contact	WVAQIDSGSTYRS-------	44 - 56	13
	IMGT	----IDSGSTYR--------	48 - 55	8
HFR3	Chothia	RSYADSVKGRFSIDRDNSKNTLYLEMDNLQPADTAVYYCRK	55 - 95	41
	AbM	--YADSVKGRFSIDRDNSKNTLYLEMDNLQPADTAVYYCRK	57 - 95	39
	Kabat	---------RFSIDRDNSKNTLYLEMDNLQPADTAVYYCRK	64 - 95	32
	Contact	--YADSVKGRFSIDRDNSKNTLYLEMDNLQPADTAVYYC--	57 - 93	37
	IMGT	-SYADSVKGRFSIDRDNSKNTLYLEMDNLQPADTAVYYC--	56 - 93	38
CDR-H3	Chothia	--GGGE	96 - 99	4
	AbM	--GGGE	96 - 99	4
	Kabat	--GGGE	96 - 99	4
	Contact	RKGGG-	94 - 98	5
	IMGT	RKGGGE	94 - 99	6
HFR4	Chothia	-RGQGTQVT	100 - 107	8
	AbM	-RGQGTQVT	100 - 107	8
	Kabat	-RGQGTQVT	100 - 107	8
	Contact	ERGQGTQVT	99 - 107	9
	IMGT	-RGQGTQVT	100 - 107	8

Accession & Annotations

Accession	CAJ55293.1
Source	abYsis-EMBL-IG AM180299 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M15
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQPGGSLRLSCAASGFTFSNWVMNWVRQAPGKGLEWVAQIDSGSTYRSYADS
VKGRFSIDRDNSKNTLYLEMDNLQPADTAVYYCRKGGGERGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactctcctgtgca
gcctctggattcacgttcagtaattgggtcatgaactgggtccgccaggctccaggaaag
gggctcgagtgggtcgcacaaattgatagtggaagtacttacagaagttatgcagactcc
gtgaagggccgattctccatcgacagagacaactccaagaacacgctatatcttgaaatg
gacaacctgcaacctgcggacacggccgtgtattactgtcgaaagggcggtggcgagcgt
ggccaggggactcaggtcacc

Data Source:

Alignment settings:

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