abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQAGGSLRLTCAASGRTFS	1 - 27	27
CDR-H1	SYSVG	28 - 32	5
HFR2	WFRQAPGNEREFVA	33 - 46	14
CDR-H2	AISWSGSSTYSADSVKG	47 - 63	17
HFR3	RFTISRDNAKNTAYLQMNSLKPEDTAVYYCAA	64 - 95	32
CDR-H3	DRSRAEWLVTNEADYDY	96 - 112	17
HFR4	WGQGTQVT	113 - 120	8
			120

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQAGGSLRLTCAAS-----	1 - 22	22
	AbM	LQQSGGGLVQAGGSLRLTCAAS-----	1 - 22	22
	Kabat	LQQSGGGLVQAGGSLRLTCAASGRTFS	1 - 27	27
	Contact	LQQSGGGLVQAGGSLRLTCAASGRTF-	1 - 26	26
	IMGT	LQQSGGGLVQAGGSLRLTCAAS-----	1 - 22	22
CDR-H1	Chothia	GRTFSSY---	23 - 29	7
	AbM	GRTFSSYSVG	23 - 32	10
	Kabat	-----SYSVG	28 - 32	5
	Contact	----SSYSVG	27 - 32	6
	IMGT	GRTFSSYS--	23 - 30	8
HFR2	Chothia	SVGWFRQAPGNEREFVAAI	30 - 48	19
	AbM	---WFRQAPGNEREFVA--	33 - 46	14
	Kabat	---WFRQAPGNEREFVA--	33 - 46	14
	Contact	---WFRQAPGNERE-----	33 - 43	11
	IMGT	-VGWFRQAPGNEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWSGSS---------	49 - 54	6
	AbM	---AISWSGSSTY-------	47 - 56	10
	Kabat	---AISWSGSSTYSADSVKG	47 - 63	17
	Contact	FVAAISWSGSSTY-------	44 - 56	13
	IMGT	----ISWSGSST--------	48 - 55	8
HFR3	Chothia	TYSADSVKGRFTISRDNAKNTAYLQMNSLKPEDTAVYYCAA	55 - 95	41
	AbM	--SADSVKGRFTISRDNAKNTAYLQMNSLKPEDTAVYYCAA	57 - 95	39
	Kabat	---------RFTISRDNAKNTAYLQMNSLKPEDTAVYYCAA	64 - 95	32
	Contact	--SADSVKGRFTISRDNAKNTAYLQMNSLKPEDTAVYYC--	57 - 93	37
	IMGT	-YSADSVKGRFTISRDNAKNTAYLQMNSLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DRSRAEWLVTNEADYDY	96 - 112	17
	AbM	--DRSRAEWLVTNEADYDY	96 - 112	17
	Kabat	--DRSRAEWLVTNEADYDY	96 - 112	17
	Contact	AADRSRAEWLVTNEADYD-	94 - 111	18
	IMGT	AADRSRAEWLVTNEADYDY	94 - 112	19
HFR4	Chothia	-WGQGTQVT	113 - 120	8
	AbM	-WGQGTQVT	113 - 120	8
	Kabat	-WGQGTQVT	113 - 120	8
	Contact	YWGQGTQVT	112 - 120	9
	IMGT	-WGQGTQVT	113 - 120	8

Accession & Annotations

Accession	CAJ55294.1
Source	abYsis-EMBL-IG AM180300 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M65
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQAGGSLRLTCAASGRTFSSYSVGWFRQAPGNEREFVAAISWSGSSTYSADS
VKGRFTISRDNAKNTAYLQMNSLKPEDTAVYYCAADRSRAEWLVTNEADYDYWGQGTQVT

DNA Sequence:

ctgcagcagtcagggggaggattggtgcaggctgggggctctctgagactcacatgtgca
gcctctggacgcaccttcagtagctattccgtgggctggttccgccaggctccagggaac
gagcgtgagtttgtagcagccattagctggagtggtagtagcacgtactcggcagactcc
gtgaagggccgattcaccatctctagagacaacgccaagaacacggcgtatctgcaaatg
aacagcctgaaacctgaggacacggccgtttattactgtgcagcagaccggtcgagggcg
gaatggttagttactaatgaggcggactatgactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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