abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGRTFS	1 - 27	27
CDR-H1	RYVMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AIVGSGSSTSYADSVKG	47 - 63	17
HFR3	RFTISRDNAKNAVYLQMNSLKPEDTAVYYCAA	64 - 95	32
CDR-H3	VLSFPSTKERDYTY	96 - 109	14
HFR4	WGQGTQVT	110 - 117	8
			117

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGRTFS	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGRTF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRTFSRY---	23 - 29	7
	AbM	GRTFSRYVMG	23 - 32	10
	Kabat	-----RYVMG	28 - 32	5
	Contact	----SRYVMG	27 - 32	6
	IMGT	GRTFSRYV--	23 - 30	8
HFR2	Chothia	VMGWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----VGSGSS---------	49 - 54	6
	AbM	---AIVGSGSSTS-------	47 - 56	10
	Kabat	---AIVGSGSSTSYADSVKG	47 - 63	17
	Contact	FVAAIVGSGSSTS-------	44 - 56	13
	IMGT	----IVGSGSST--------	48 - 55	8
HFR3	Chothia	TSYADSVKGRFTISRDNAKNAVYLQMNSLKPEDTAVYYCAA	55 - 95	41
	AbM	--YADSVKGRFTISRDNAKNAVYLQMNSLKPEDTAVYYCAA	57 - 95	39
	Kabat	---------RFTISRDNAKNAVYLQMNSLKPEDTAVYYCAA	64 - 95	32
	Contact	--YADSVKGRFTISRDNAKNAVYLQMNSLKPEDTAVYYC--	57 - 93	37
	IMGT	-SYADSVKGRFTISRDNAKNAVYLQMNSLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--VLSFPSTKERDYTY	96 - 109	14
	AbM	--VLSFPSTKERDYTY	96 - 109	14
	Kabat	--VLSFPSTKERDYTY	96 - 109	14
	Contact	AAVLSFPSTKERDYT-	94 - 108	15
	IMGT	AAVLSFPSTKERDYTY	94 - 109	16
HFR4	Chothia	-WGQGTQVT	110 - 117	8
	AbM	-WGQGTQVT	110 - 117	8
	Kabat	-WGQGTQVT	110 - 117	8
	Contact	YWGQGTQVT	109 - 117	9
	IMGT	-WGQGTQVT	110 - 117	8

Accession & Annotations

Accession	CAJ55295.1
Source	abYsis-EMBL-IG AM180301 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M70
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGRTFSRYVMGWFRQAPGKEREFVAAIVGSGSSTSYADS
VKGRFTISRDNAKNAVYLQMNSLKPEDTAVYYCAAVLSFPSTKERDYTYWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcaccttcagtagatatgtcatgggctggttccgccaggctccagggaag
gagcgtgagtttgtagcagctattgtcgggagtggtagtagtacatcgtatgcagactcc
gtgaagggccgattcaccatctccagagacaacgccaagaatgcggtgtatctgcaaatg
aacagcctgaaacctgaggacacggccgtttattactgtgcagcagtcctgtctttccca
tccacaaaagagagggactatacctactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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