abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQPGGSLRLSCAASGSISR	1 - 27	27
CDR-H1	FNDMA	28 - 32	5
HFR2	WSRQAPGEQREFVA	33 - 46	14
CDR-H2	RIDSGGNTRYADSVKG	47 - 62	16
HFR3	RFTISRDNAKNTVYLQMTSLKVEDTAVYHCNV	63 - 94	32
CDR-H3	QLPTGWVRRRGSDD	95 - 108	14
HFR4	WGQGTRVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQPGGSLRLSCAASGSISR	1 - 27	27
	Contact	LQESGGGLVQPGGSLRLSCAASGSIS-	1 - 26	26
	IMGT	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GSISRFN---	23 - 29	7
	AbM	GSISRFNDMA	23 - 32	10
	Kabat	-----FNDMA	28 - 32	5
	Contact	----RFNDMA	27 - 32	6
	IMGT	GSISRFND--	23 - 30	8
HFR2	Chothia	DMAWSRQAPGEQREFVARI	30 - 48	19
	AbM	---WSRQAPGEQREFVA--	33 - 46	14
	Kabat	---WSRQAPGEQREFVA--	33 - 46	14
	Contact	---WSRQAPGEQRE-----	33 - 43	11
	IMGT	-MAWSRQAPGEQREFVAR-	31 - 47	17
CDR-H2	Chothia	-----DSGGN---------	49 - 53	5
	AbM	---RIDSGGNTR-------	47 - 55	9
	Kabat	---RIDSGGNTRYADSVKG	47 - 62	16
	Contact	FVARIDSGGNTR-------	44 - 55	12
	IMGT	----IDSGGNT--------	48 - 54	7
HFR3	Chothia	TRYADSVKGRFTISRDNAKNTVYLQMTSLKVEDTAVYHCNV	54 - 94	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMTSLKVEDTAVYHCNV	56 - 94	39
	Kabat	---------RFTISRDNAKNTVYLQMTSLKVEDTAVYHCNV	63 - 94	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMTSLKVEDTAVYHC--	56 - 92	37
	IMGT	-RYADSVKGRFTISRDNAKNTVYLQMTSLKVEDTAVYHC--	55 - 92	38
CDR-H3	Chothia	--QLPTGWVRRRGSDD	95 - 108	14
	AbM	--QLPTGWVRRRGSDD	95 - 108	14
	Kabat	--QLPTGWVRRRGSDD	95 - 108	14
	Contact	NVQLPTGWVRRRGSD-	93 - 107	15
	IMGT	NVQLPTGWVRRRGSDD	93 - 108	16
HFR4	Chothia	-WGQGTRVT	109 - 116	8
	AbM	-WGQGTRVT	109 - 116	8
	Kabat	-WGQGTRVT	109 - 116	8
	Contact	DWGQGTRVT	108 - 116	9
	IMGT	-WGQGTRVT	109 - 116	8

Accession & Annotations

Accession	CAJ55299.1
Source	abYsis-EMBL-IG AM180306 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M97
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQPGGSLRLSCAASGSISRFNDMAWSRQAPGEQREFVARIDSGGNTRYADSV
KGRFTISRDNAKNTVYLQMTSLKVEDTAVYHCNVQLPTGWVRRRGSDDWGQGTRVT

DNA Sequence:

ctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactctcctgtgca
gcctcaggaagcatcagccgtttcaatgacatggcctggtcccgccaggctccaggagag
cagcgcgagtttgtcgcacgtattgatagtgggggtaatacacggtatgcggactccgtg
aagggccgattcaccatctccagagacaacgccaagaacacggtatatctgcaaatgacc
agcctgaaagttgaggacacggccgtttatcactgtaatgtccagctaccgacgggttgg
gtacgacgaaggggttctgacgactggggccaggggacccgggtcacc

Data Source:

Alignment settings:

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