abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQAGGSLRLSCTASGRTFN	1 - 27	27
CDR-H1	SYAMG	28 - 32	5
HFR2	WFRQAPGKKRAFVA	33 - 46	14
CDR-H2	AISWGGGSTSYEDSVKG	47 - 63	17
HFR3	RFTISRDNDKNTVYLRMNSLKPEDTAVYYCAQ	64 - 95	32
CDR-H3	GDSTHHIRALSPEY	96 - 109	14
HFR4	WGQGTQVT	110 - 117	8
			117

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQAGGSLRLSCTAS-----	1 - 22	22
	AbM	LQQSGGGLVQAGGSLRLSCTAS-----	1 - 22	22
	Kabat	LQQSGGGLVQAGGSLRLSCTASGRTFN	1 - 27	27
	Contact	LQQSGGGLVQAGGSLRLSCTASGRTF-	1 - 26	26
	IMGT	LQQSGGGLVQAGGSLRLSCTAS-----	1 - 22	22
CDR-H1	Chothia	GRTFNSY---	23 - 29	7
	AbM	GRTFNSYAMG	23 - 32	10
	Kabat	-----SYAMG	28 - 32	5
	Contact	----NSYAMG	27 - 32	6
	IMGT	GRTFNSYA--	23 - 30	8
HFR2	Chothia	AMGWFRQAPGKKRAFVAAI	30 - 48	19
	AbM	---WFRQAPGKKRAFVA--	33 - 46	14
	Kabat	---WFRQAPGKKRAFVA--	33 - 46	14
	Contact	---WFRQAPGKKRA-----	33 - 43	11
	IMGT	-MGWFRQAPGKKRAFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWGGGS---------	49 - 54	6
	AbM	---AISWGGGSTS-------	47 - 56	10
	Kabat	---AISWGGGSTSYEDSVKG	47 - 63	17
	Contact	FVAAISWGGGSTS-------	44 - 56	13
	IMGT	----ISWGGGST--------	48 - 55	8
HFR3	Chothia	TSYEDSVKGRFTISRDNDKNTVYLRMNSLKPEDTAVYYCAQ	55 - 95	41
	AbM	--YEDSVKGRFTISRDNDKNTVYLRMNSLKPEDTAVYYCAQ	57 - 95	39
	Kabat	---------RFTISRDNDKNTVYLRMNSLKPEDTAVYYCAQ	64 - 95	32
	Contact	--YEDSVKGRFTISRDNDKNTVYLRMNSLKPEDTAVYYC--	57 - 93	37
	IMGT	-SYEDSVKGRFTISRDNDKNTVYLRMNSLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--GDSTHHIRALSPEY	96 - 109	14
	AbM	--GDSTHHIRALSPEY	96 - 109	14
	Kabat	--GDSTHHIRALSPEY	96 - 109	14
	Contact	AQGDSTHHIRALSPE-	94 - 108	15
	IMGT	AQGDSTHHIRALSPEY	94 - 109	16
HFR4	Chothia	-WGQGTQVT	110 - 117	8
	AbM	-WGQGTQVT	110 - 117	8
	Kabat	-WGQGTQVT	110 - 117	8
	Contact	YWGQGTQVT	109 - 117	9
	IMGT	-WGQGTQVT	110 - 117	8

Accession & Annotations

Accession	CAJ55300.1
Source	abYsis-EMBL-IG AM180307 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M107
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQAGGSLRLSCTASGRTFNSYAMGWFRQAPGKKRAFVAAISWGGGSTSYEDS
VKGRFTISRDNDKNTVYLRMNSLKPEDTAVYYCAQGDSTHHIRALSPEYWGQGTQVT

DNA Sequence:

ctgcagcagtctgggggaggattggtgcaggctgggggttctctgagactctcctgtaca
gcctctggacgcaccttcaatagctatgccatgggctggttccgccaggctccagggaag
aagagagcgtttgtagctgcgattagctggggtggtggtagcacatcctatgaagactcc
gtgaagggccgattcaccatctccagagacaatgacaaaaacacggtgtatctgcgaatg
aacagtctgaaacctgaggacacggccgtttattactgtgcacagggggattctactcat
catattagggctttaagtccagaatactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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