abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGSIRT	1 - 27	27
CDR-H1	FNTMG	28 - 32	5
HFR2	WYRQGTGNERELIA	33 - 46	14
CDR-H2	SITNSGSTNYADSVKG	47 - 62	16
HFR3	RFTISRDNAINTVYLQMNSLKPEDTAVYYCNI	63 - 94	32
CDR-H3	DVQGGGWGSIQRY	95 - 107	13
HFR4	WGQGT	108 - 112	5
			112

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGSIRT	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGSIR-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GSIRTFN---	23 - 29	7
	AbM	GSIRTFNTMG	23 - 32	10
	Kabat	-----FNTMG	28 - 32	5
	Contact	----TFNTMG	27 - 32	6
	IMGT	GSIRTFNT--	23 - 30	8
HFR2	Chothia	TMGWYRQGTGNERELIASI	30 - 48	19
	AbM	---WYRQGTGNERELIA--	33 - 46	14
	Kabat	---WYRQGTGNERELIA--	33 - 46	14
	Contact	---WYRQGTGNERE-----	33 - 43	11
	IMGT	-MGWYRQGTGNERELIAS-	31 - 47	17
CDR-H2	Chothia	-----TNSGS---------	49 - 53	5
	AbM	---SITNSGSTN-------	47 - 55	9
	Kabat	---SITNSGSTNYADSVKG	47 - 62	16
	Contact	LIASITNSGSTN-------	44 - 55	12
	IMGT	----ITNSGST--------	48 - 54	7
HFR3	Chothia	TNYADSVKGRFTISRDNAINTVYLQMNSLKPEDTAVYYCNI	54 - 94	41
	AbM	--YADSVKGRFTISRDNAINTVYLQMNSLKPEDTAVYYCNI	56 - 94	39
	Kabat	---------RFTISRDNAINTVYLQMNSLKPEDTAVYYCNI	63 - 94	32
	Contact	--YADSVKGRFTISRDNAINTVYLQMNSLKPEDTAVYYC--	56 - 92	37
	IMGT	-NYADSVKGRFTISRDNAINTVYLQMNSLKPEDTAVYYC--	55 - 92	38
CDR-H3	Chothia	--DVQGGGWGSIQRY	95 - 107	13
	AbM	--DVQGGGWGSIQRY	95 - 107	13
	Kabat	--DVQGGGWGSIQRY	95 - 107	13
	Contact	NIDVQGGGWGSIQR-	93 - 106	14
	IMGT	NIDVQGGGWGSIQRY	93 - 107	15
HFR4	Chothia	-WGQGT	108 - 112	5
	AbM	-WGQGT	108 - 112	5
	Kabat	-WGQGT	108 - 112	5
	Contact	YWGQGT	107 - 112	6
	IMGT	-WGQGT	108 - 112	5

Accession & Annotations

Accession	CAJ55319.1
Source	abYsis-EMBL-IG AM180308 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M117
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	abYsis-EMBL-IG: CAJ55318.1
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGSIRTFNTMGWYRQGTGNERELIASITNSGSTNYADSV
KGRFTISRDNAINTVYLQMNSLKPEDTAVYYCNIDVQGGGWGSIQRYWGQGT

DNA Sequence:

ctgcaggagtcagggggaggcttggtgcaggctggggggtctctgagactctcctgtgca
gcctctggaagcatccgcactttcaataccatgggttggtaccgccagggtacagggaac
gagcgcgagttgatcgcaagtattactaatagtggtagcacaaactatgcagactccgtg
aagggccgattcaccatctccagagacaacgccatcaacacggtgtatctgcaaatgaac
agcctgaaacctgaggacacggccgtgtattactgtaatatagacgtacaagggggtggt
tggggttcgattcagcgatactggggccaggggacctaggtcacc

Data Source:

Alignment settings:

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