abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCATSGRTWN	1 - 27	27
CDR-H1	PSAMG	28 - 32	5
HFR2	WFRQAPGKGREFVA	33 - 46	14
CDR-H2	AVSRGGGSVYYADSVKG	47 - 63	17
HFR3	RFTISREVDKNAVYLQMNSLKSEDTAVYYCAA	64 - 95	32
CDR-H3	QSPGMSGTYSRSDVYPY	96 - 112	17
HFR4	WGQGTQVT	113 - 120	8
			120

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCATS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCATS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCATSGRTWN	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCATSGRTW-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCATS-----	1 - 22	22
CDR-H1	Chothia	GRTWNPS---	23 - 29	7
	AbM	GRTWNPSAMG	23 - 32	10
	Kabat	-----PSAMG	28 - 32	5
	Contact	----NPSAMG	27 - 32	6
	IMGT	GRTWNPSA--	23 - 30	8
HFR2	Chothia	AMGWFRQAPGKGREFVAAV	30 - 48	19
	AbM	---WFRQAPGKGREFVA--	33 - 46	14
	Kabat	---WFRQAPGKGREFVA--	33 - 46	14
	Contact	---WFRQAPGKGRE-----	33 - 43	11
	IMGT	-MGWFRQAPGKGREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SRGGGS---------	49 - 54	6
	AbM	---AVSRGGGSVY-------	47 - 56	10
	Kabat	---AVSRGGGSVYYADSVKG	47 - 63	17
	Contact	FVAAVSRGGGSVY-------	44 - 56	13
	IMGT	----VSRGGGSV--------	48 - 55	8
HFR3	Chothia	VYYADSVKGRFTISREVDKNAVYLQMNSLKSEDTAVYYCAA	55 - 95	41
	AbM	--YADSVKGRFTISREVDKNAVYLQMNSLKSEDTAVYYCAA	57 - 95	39
	Kabat	---------RFTISREVDKNAVYLQMNSLKSEDTAVYYCAA	64 - 95	32
	Contact	--YADSVKGRFTISREVDKNAVYLQMNSLKSEDTAVYYC--	57 - 93	37
	IMGT	-YYADSVKGRFTISREVDKNAVYLQMNSLKSEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--QSPGMSGTYSRSDVYPY	96 - 112	17
	AbM	--QSPGMSGTYSRSDVYPY	96 - 112	17
	Kabat	--QSPGMSGTYSRSDVYPY	96 - 112	17
	Contact	AAQSPGMSGTYSRSDVYP-	94 - 111	18
	IMGT	AAQSPGMSGTYSRSDVYPY	94 - 112	19
HFR4	Chothia	-WGQGTQVT	113 - 120	8
	AbM	-WGQGTQVT	113 - 120	8
	Kabat	-WGQGTQVT	113 - 120	8
	Contact	YWGQGTQVT	112 - 120	9
	IMGT	-WGQGTQVT	113 - 120	8

Accession & Annotations

Accession	CAJ55320.1
Source	abYsis-EMBL-IG AM180309 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M118
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCATSGRTWNPSAMGWFRQAPGKGREFVAAVSRGGGSVYYADS
VKGRFTISREVDKNAVYLQMNSLKSEDTAVYYCAAQSPGMSGTYSRSDVYPYWGQGTQVT

DNA Sequence:

ctgcaggagtcagggggaggcttggtgcaggctggaggctctctgagactctcctgtgca
acatctggacgcacctggaatcccagtgccatgggctggttccgccaggctccagggaag
gggcgtgagtttgttgcagcggttagtcggggtggtggtagtgtatattatgcagactcc
gtgaagggccgattcaccatctccagagaggttgacaagaacgcggtgtatctccaaatg
aacagcctgaaatctgaggacacggccgtttattactgtgcagcccaaagccctgggatg
agtggtacttattctcggtctgatgtgtatccctactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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