abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGRTF	1 - 26	26
CDR-H1	SRYG	27 - 30	4
HFR2	WFRQAPGKEREIVA	31 - 44	14
CDR-H2	SIRWSSGSTYYADSVKG	45 - 61	17
HFR3	RFTISRDNAKNTVYLQMNGLKPEDTAVYSCAA	62 - 93	32
CDR-H3	SSLYLALQRAEYDY	94 - 107	14
HFR4	WGQGTQVT	108 - 115	8
			115

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGRTF	1 - 26	26
	Contact	LQESGGGLVQAGGSLRLSCAASGRTF	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS----	1 - 22	22
CDR-H1	Chothia	GRTFS---	23 - 27	5
	AbM	GRTFSRYG	23 - 30	8
	Kabat	----SRYG	27 - 30	4
	Contact	----SRYG	27 - 30	4
	IMGT	GRTFSR--	23 - 28	6
HFR2	Chothia	RYGWFRQAPGKEREIVASI	28 - 46	19
	AbM	---WFRQAPGKEREIVA--	31 - 44	14
	Kabat	---WFRQAPGKEREIVA--	31 - 44	14
	Contact	---WFRQAPGKERE-----	31 - 41	11
	IMGT	-YGWFRQAPGKEREIVAS-	29 - 45	17
CDR-H2	Chothia	-----RWSSGS---------	47 - 52	6
	AbM	---SIRWSSGSTY-------	45 - 54	10
	Kabat	---SIRWSSGSTYYADSVKG	45 - 61	17
	Contact	IVASIRWSSGSTY-------	42 - 54	13
	IMGT	----IRWSSGST--------	46 - 53	8
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTVYLQMNGLKPEDTAVYSCAA	53 - 93	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNGLKPEDTAVYSCAA	55 - 93	39
	Kabat	---------RFTISRDNAKNTVYLQMNGLKPEDTAVYSCAA	62 - 93	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNGLKPEDTAVYSC--	55 - 91	37
	IMGT	-YYADSVKGRFTISRDNAKNTVYLQMNGLKPEDTAVYSC--	54 - 91	38
CDR-H3	Chothia	--SSLYLALQRAEYDY	94 - 107	14
	AbM	--SSLYLALQRAEYDY	94 - 107	14
	Kabat	--SSLYLALQRAEYDY	94 - 107	14
	Contact	AASSLYLALQRAEYD-	92 - 106	15
	IMGT	AASSLYLALQRAEYDY	92 - 107	16
HFR4	Chothia	-WGQGTQVT	108 - 115	8
	AbM	-WGQGTQVT	108 - 115	8
	Kabat	-WGQGTQVT	108 - 115	8
	Contact	YWGQGTQVT	107 - 115	9
	IMGT	-WGQGTQVT	108 - 115	8

Accession & Annotations

Accession	CAJ55302.1
Source	abYsis-EMBL-IG AM180311 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M133
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGRTFSRYGWFRQAPGKEREIVASIRWSSGSTYYADSVK
GRFTISRDNAKNTVYLQMNGLKPEDTAVYSCAASSLYLALQRAEYDYWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcacctttagtaggtatggctggttccggcaggctccagggaaggagcgt
gagatagtagcatctattagatggagtagtggtagcacatactatgcagactccgtgaag
ggccgattcaccatctccagagacaacgccaagaacacggtgtatctgcaaatgaacggc
ctcaaacctgaggacacggccgtttattcttgtgcagcgtcgtctctgtacctggctctc
caacgggccgagtatgactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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