abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLTQAGGSLRLSCAASGRTFG	1 - 27	27
CDR-H1	TYAVG	28 - 32	5
HFR2	WFRQAPGKGREFVG	33 - 46	14
CDR-H2	AIRRSGGSTYYTDSVKG	47 - 63	17
HFR3	RFTISRDNAKNTVYLQMNGLKPEDTAVYYCAA	64 - 95	32
CDR-H3	RRHGEYDY	96 - 103	8
HFR4	WGQGTQVT	104 - 111	8
			111

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLTQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQQSGGGLTQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQQSGGGLTQAGGSLRLSCAASGRTFG	1 - 27	27
	Contact	LQQSGGGLTQAGGSLRLSCAASGRTF-	1 - 26	26
	IMGT	LQQSGGGLTQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRTFGTY---	23 - 29	7
	AbM	GRTFGTYAVG	23 - 32	10
	Kabat	-----TYAVG	28 - 32	5
	Contact	----GTYAVG	27 - 32	6
	IMGT	GRTFGTYA--	23 - 30	8
HFR2	Chothia	AVGWFRQAPGKGREFVGAI	30 - 48	19
	AbM	---WFRQAPGKGREFVG--	33 - 46	14
	Kabat	---WFRQAPGKGREFVG--	33 - 46	14
	Contact	---WFRQAPGKGRE-----	33 - 43	11
	IMGT	-VGWFRQAPGKGREFVGA-	31 - 47	17
CDR-H2	Chothia	-----RRSGGS---------	49 - 54	6
	AbM	---AIRRSGGSTY-------	47 - 56	10
	Kabat	---AIRRSGGSTYYTDSVKG	47 - 63	17
	Contact	FVGAIRRSGGSTY-------	44 - 56	13
	IMGT	----IRRSGGST--------	48 - 55	8
HFR3	Chothia	TYYTDSVKGRFTISRDNAKNTVYLQMNGLKPEDTAVYYCAA	55 - 95	41
	AbM	--YTDSVKGRFTISRDNAKNTVYLQMNGLKPEDTAVYYCAA	57 - 95	39
	Kabat	---------RFTISRDNAKNTVYLQMNGLKPEDTAVYYCAA	64 - 95	32
	Contact	--YTDSVKGRFTISRDNAKNTVYLQMNGLKPEDTAVYYC--	57 - 93	37
	IMGT	-YYTDSVKGRFTISRDNAKNTVYLQMNGLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--RRHGEYDY	96 - 103	8
	AbM	--RRHGEYDY	96 - 103	8
	Kabat	--RRHGEYDY	96 - 103	8
	Contact	AARRHGEYD-	94 - 102	9
	IMGT	AARRHGEYDY	94 - 103	10
HFR4	Chothia	-WGQGTQVT	104 - 111	8
	AbM	-WGQGTQVT	104 - 111	8
	Kabat	-WGQGTQVT	104 - 111	8
	Contact	YWGQGTQVT	103 - 111	9
	IMGT	-WGQGTQVT	104 - 111	8

Accession & Annotations

Accession	CAJ55303.1
Source	abYsis-EMBL-IG AM180312 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M138
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLTQAGGSLRLSCAASGRTFGTYAVGWFRQAPGKGREFVGAIRRSGGSTYYTDS
VKGRFTISRDNAKNTVYLQMNGLKPEDTAVYYCAARRHGEYDYWGQGTQVT

DNA Sequence:

ctgcagcagtcagggggaggattgacgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcaccttcggcacctatgccgtgggctggttccgccaggctccagggaag
ggccgtgagtttgtaggagctattagacggagtggtggtagcacatactatacagactcc
gtgaagggccgattcaccatctccagagacaacgccaagaacacggtgtatctgcaaatg
aacggcctgaaacctgaggatacggccgtttattattgtgcagcaaggaggcacggggag
tatgactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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