abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGVSLRLSCAASGSTFS	1 - 27	27
CDR-H1	SYVMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AITRRGGRGVYSDSVKG	47 - 63	17
HFR3	RFTISRDNAKNTLYLQMNSLKPEDTAVYYCAA	64 - 95	32
CDR-H3	QRRGIPRYEY	96 - 105	10
HFR4	WGQGTQVT	106 - 113	8
			113

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGVSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGVSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGVSLRLSCAASGSTFS	1 - 27	27
	Contact	LQESGGGLVQAGVSLRLSCAASGSTF-	1 - 26	26
	IMGT	LQESGGGLVQAGVSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GSTFSSY---	23 - 29	7
	AbM	GSTFSSYVMG	23 - 32	10
	Kabat	-----SYVMG	28 - 32	5
	Contact	----SSYVMG	27 - 32	6
	IMGT	GSTFSSYV--	23 - 30	8
HFR2	Chothia	VMGWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----TRRGGR---------	49 - 54	6
	AbM	---AITRRGGRGV-------	47 - 56	10
	Kabat	---AITRRGGRGVYSDSVKG	47 - 63	17
	Contact	FVAAITRRGGRGV-------	44 - 56	13
	IMGT	----ITRRGGRG--------	48 - 55	8
HFR3	Chothia	GVYSDSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCAA	55 - 95	41
	AbM	--YSDSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCAA	57 - 95	39
	Kabat	---------RFTISRDNAKNTLYLQMNSLKPEDTAVYYCAA	64 - 95	32
	Contact	--YSDSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYC--	57 - 93	37
	IMGT	-VYSDSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--QRRGIPRYEY	96 - 105	10
	AbM	--QRRGIPRYEY	96 - 105	10
	Kabat	--QRRGIPRYEY	96 - 105	10
	Contact	AAQRRGIPRYE-	94 - 104	11
	IMGT	AAQRRGIPRYEY	94 - 105	12
HFR4	Chothia	-WGQGTQVT	106 - 113	8
	AbM	-WGQGTQVT	106 - 113	8
	Kabat	-WGQGTQVT	106 - 113	8
	Contact	YWGQGTQVT	105 - 113	9
	IMGT	-WGQGTQVT	106 - 113	8

Accession & Annotations

Accession	CAJ55304.1
Source	abYsis-EMBL-IG AM180313 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M146
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGVSLRLSCAASGSTFSSYVMGWFRQAPGKEREFVAAITRRGGRGVYSDS
VKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCAAQRRGIPRYEYWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggattggtgcaggctggagtctctctgagactctcctgtgca
gcctctggaagcaccttcagtagctatgtcatgggctggttccgccaggctccaggcaag
gagcgtgagtttgtagcagctataaccaggagaggtggcaggggagtctattcagactcc
gtgaagggccgattcaccatctccagagacaacgccaagaacacactgtatctgcagatg
aacagcctgaaacctgaggacacggccgtgtattactgtgcggcacagcgccgtggaata
ccccggtatgagtattggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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