abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQAGDSLRLSCAASGRTFT	1 - 27	27
CDR-H1	LEAMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AIDWRSGSKMDYADSVKG	47 - 64	18
HFR3	RFTISRDIAKNTVYLQMNSLKPEDTAVYYCAA	65 - 96	32
CDR-H3	DRDTLRISGAGGAMDY	97 - 112	16
HFR4	WGQGTLVT	113 - 120	8
			120

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQAGDSLRLSCAAS-----	1 - 22	22
	AbM	LQQSGGGLVQAGDSLRLSCAAS-----	1 - 22	22
	Kabat	LQQSGGGLVQAGDSLRLSCAASGRTFT	1 - 27	27
	Contact	LQQSGGGLVQAGDSLRLSCAASGRTF-	1 - 26	26
	IMGT	LQQSGGGLVQAGDSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRTFTLE---	23 - 29	7
	AbM	GRTFTLEAMG	23 - 32	10
	Kabat	-----LEAMG	28 - 32	5
	Contact	----TLEAMG	27 - 32	6
	IMGT	GRTFTLEA--	23 - 30	8
HFR2	Chothia	AMGWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----DWRSGSK---------	49 - 55	7
	AbM	---AIDWRSGSKMD-------	47 - 57	11
	Kabat	---AIDWRSGSKMDYADSVKG	47 - 64	18
	Contact	FVAAIDWRSGSKMD-------	44 - 57	14
	IMGT	----IDWRSGSKM--------	48 - 56	9
HFR3	Chothia	MDYADSVKGRFTISRDIAKNTVYLQMNSLKPEDTAVYYCAA	56 - 96	41
	AbM	--YADSVKGRFTISRDIAKNTVYLQMNSLKPEDTAVYYCAA	58 - 96	39
	Kabat	---------RFTISRDIAKNTVYLQMNSLKPEDTAVYYCAA	65 - 96	32
	Contact	--YADSVKGRFTISRDIAKNTVYLQMNSLKPEDTAVYYC--	58 - 94	37
	IMGT	-DYADSVKGRFTISRDIAKNTVYLQMNSLKPEDTAVYYC--	57 - 94	38
CDR-H3	Chothia	--DRDTLRISGAGGAMDY	97 - 112	16
	AbM	--DRDTLRISGAGGAMDY	97 - 112	16
	Kabat	--DRDTLRISGAGGAMDY	97 - 112	16
	Contact	AADRDTLRISGAGGAMD-	95 - 111	17
	IMGT	AADRDTLRISGAGGAMDY	95 - 112	18
HFR4	Chothia	-WGQGTLVT	113 - 120	8
	AbM	-WGQGTLVT	113 - 120	8
	Kabat	-WGQGTLVT	113 - 120	8
	Contact	YWGQGTLVT	112 - 120	9
	IMGT	-WGQGTLVT	113 - 120	8

Accession & Annotations

Accession	CAJ55305.1
Source	abYsis-EMBL-IG AM180314 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M164
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQAGDSLRLSCAASGRTFTLEAMGWFRQAPGKEREFVAAIDWRSGSKMDYAD
SVKGRFTISRDIAKNTVYLQMNSLKPEDTAVYYCAADRDTLRISGAGGAMDYWGQGTLVT

DNA Sequence:

ctgcagcagtcagggggaggattggtgcaggctggggactctctgagactctcctgtgca
gcctctggtcgcaccttcactcttgaggccatgggctggttccgccaggctccagggaag
gagcgtgagtttgtagcggctattgactggaggagtggtagtaaaatggactatgcagac
tccgtgaagggccgattcaccatctccagagacatcgccaagaacacggtgtatctgcaa
atgaacagcctgaaacctgaggacacggccgtctattactgtgcagcagatagagatact
ttgcgtatttcgggcgctggcggcgccatggactactggggccaagggaccctggtcacc

Data Source:

Alignment settings:

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