abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQAGGSLRLSCAASGRTFS	1 - 27	27
CDR-H1	SSLMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	DIDWNGSVISYTDSVKG	47 - 63	17
HFR3	RFTISRDNAKNTVWLQMNSLKPEDTAVYYCAQ	64 - 95	32
CDR-H3	AALEYCTGTGCRYGY	96 - 110	15
HFR4	WGQGTQVT	111 - 118	8
			118

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQQSGGGLVQAGGSLRLSCAASGRTFS	1 - 27	27
	Contact	LQQSGGGLVQAGGSLRLSCAASGRTF-	1 - 26	26
	IMGT	LQQSGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRTFSSS---	23 - 29	7
	AbM	GRTFSSSLMG	23 - 32	10
	Kabat	-----SSLMG	28 - 32	5
	Contact	----SSSLMG	27 - 32	6
	IMGT	GRTFSSSL--	23 - 30	8
HFR2	Chothia	LMGWFRQAPGKEREFVADI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAD-	31 - 47	17
CDR-H2	Chothia	-----DWNGSV---------	49 - 54	6
	AbM	---DIDWNGSVIS-------	47 - 56	10
	Kabat	---DIDWNGSVISYTDSVKG	47 - 63	17
	Contact	FVADIDWNGSVIS-------	44 - 56	13
	IMGT	----IDWNGSVI--------	48 - 55	8
HFR3	Chothia	ISYTDSVKGRFTISRDNAKNTVWLQMNSLKPEDTAVYYCAQ	55 - 95	41
	AbM	--YTDSVKGRFTISRDNAKNTVWLQMNSLKPEDTAVYYCAQ	57 - 95	39
	Kabat	---------RFTISRDNAKNTVWLQMNSLKPEDTAVYYCAQ	64 - 95	32
	Contact	--YTDSVKGRFTISRDNAKNTVWLQMNSLKPEDTAVYYC--	57 - 93	37
	IMGT	-SYTDSVKGRFTISRDNAKNTVWLQMNSLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--AALEYCTGTGCRYGY	96 - 110	15
	AbM	--AALEYCTGTGCRYGY	96 - 110	15
	Kabat	--AALEYCTGTGCRYGY	96 - 110	15
	Contact	AQAALEYCTGTGCRYG-	94 - 109	16
	IMGT	AQAALEYCTGTGCRYGY	94 - 110	17
HFR4	Chothia	-WGQGTQVT	111 - 118	8
	AbM	-WGQGTQVT	111 - 118	8
	Kabat	-WGQGTQVT	111 - 118	8
	Contact	YWGQGTQVT	110 - 118	9
	IMGT	-WGQGTQVT	111 - 118	8

Accession & Annotations

Accession	CAJ57593.2
Source	abYsis-EMBL-IG AM180317 Submitted 15-JAN-2006 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M173
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQAGGSLRLSCAASGRTFSSSLMGWFRQAPGKEREFVADIDWNGSVISYTDS
VKGRFTISRDNAKNTVWLQMNSLKPEDTAVYYCAQAALEYCTGTGCRYGYWGQGTQVT

DNA Sequence:

ctgcagcagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcacctttagtagctctctcatgggctggttccgccaggctccagggaag
tagcgtgagtttgtagcagatattgactggaatggtagtgtgataagctacacagactcc
gtgaagggccgattcaccatctccagagacaacgccaagaacacggtgtggctgcaaatg
aacagtctgaaacctgaggacacggccgtttattactgtgcacaggcggcgttagaatac
tgtacaggcactgggtgccgatatggctactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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