abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQPGGSLRLSCAASGDFFS	1 - 27	27
CDR-H1	INNMG	28 - 32	5
HFR2	WYRQAPGKQRELVA	33 - 46	14
CDR-H2	TISSRGSTNYADSVKG	47 - 62	16
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	63 - 94	32
CDR-H3	DETSGWASLRHY	95 - 106	12
HFR4	WGQGTQVT	107 - 114	8
			114

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQPGGSLRLSCAASGDFFS	1 - 27	27
	Contact	LQESGGGLVQPGGSLRLSCAASGDFF-	1 - 26	26
	IMGT	LQESGGGLVQPGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GDFFSIN---	23 - 29	7
	AbM	GDFFSINNMG	23 - 32	10
	Kabat	-----INNMG	28 - 32	5
	Contact	----SINNMG	27 - 32	6
	IMGT	GDFFSINN--	23 - 30	8
HFR2	Chothia	NMGWYRQAPGKQRELVATI	30 - 48	19
	AbM	---WYRQAPGKQRELVA--	33 - 46	14
	Kabat	---WYRQAPGKQRELVA--	33 - 46	14
	Contact	---WYRQAPGKQRE-----	33 - 43	11
	IMGT	-MGWYRQAPGKQRELVAT-	31 - 47	17
CDR-H2	Chothia	-----SSRGS---------	49 - 53	5
	AbM	---TISSRGSTN-------	47 - 55	9
	Kabat	---TISSRGSTNYADSVKG	47 - 62	16
	Contact	LVATISSRGSTN-------	44 - 55	12
	IMGT	----ISSRGST--------	48 - 54	7
HFR3	Chothia	TNYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	54 - 94	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	56 - 94	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAVYYCNA	63 - 94	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	56 - 92	37
	IMGT	-NYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	55 - 92	38
CDR-H3	Chothia	--DETSGWASLRHY	95 - 106	12
	AbM	--DETSGWASLRHY	95 - 106	12
	Kabat	--DETSGWASLRHY	95 - 106	12
	Contact	NADETSGWASLRH-	93 - 105	13
	IMGT	NADETSGWASLRHY	93 - 106	14
HFR4	Chothia	-WGQGTQVT	107 - 114	8
	AbM	-WGQGTQVT	107 - 114	8
	Kabat	-WGQGTQVT	107 - 114	8
	Contact	YWGQGTQVT	106 - 114	9
	IMGT	-WGQGTQVT	107 - 114	8

Accession & Annotations

Accession	CAJ55308.1
Source	abYsis-EMBL-IG AM180318 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M175
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQPGGSLRLSCAASGDFFSINNMGWYRQAPGKQRELVATISSRGSTNYADSV
KGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNADETSGWASLRHYWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggcttggtgcagcctggggggtctctgagactctcctgtgca
gcctctggagacttcttcagtatcaataacatgggctggtaccgccaggctccagggaag
cagcgcgagttggtcgcaactattagtagtcgtggtagcacaaactatgcagactccgtg
aagggccgattcaccatctccagagacaacgccaagaacacggtgtatctgcaaatgaac
agcctgaaacctgaggacacggccgtctattactgtaatgcagacgagacgtcgggttgg
gcatccctaaggcactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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