abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGRTFD	1 - 27	27
CDR-H1	NWTLG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AITWTGGVTDYADSVKG	47 - 63	17
HFR3	RFTISRDKAKNTVALQMNSLKPENTAVYYCAA	64 - 95	32
CDR-H3	RAGWDLNRFDYRY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGRTFD	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGRTF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRTFDNW---	23 - 29	7
	AbM	GRTFDNWTLG	23 - 32	10
	Kabat	-----NWTLG	28 - 32	5
	Contact	----DNWTLG	27 - 32	6
	IMGT	GRTFDNWT--	23 - 30	8
HFR2	Chothia	TLGWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-LGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----TWTGGV---------	49 - 54	6
	AbM	---AITWTGGVTD-------	47 - 56	10
	Kabat	---AITWTGGVTDYADSVKG	47 - 63	17
	Contact	FVAAITWTGGVTD-------	44 - 56	13
	IMGT	----ITWTGGVT--------	48 - 55	8
HFR3	Chothia	TDYADSVKGRFTISRDKAKNTVALQMNSLKPENTAVYYCAA	55 - 95	41
	AbM	--YADSVKGRFTISRDKAKNTVALQMNSLKPENTAVYYCAA	57 - 95	39
	Kabat	---------RFTISRDKAKNTVALQMNSLKPENTAVYYCAA	64 - 95	32
	Contact	--YADSVKGRFTISRDKAKNTVALQMNSLKPENTAVYYC--	57 - 93	37
	IMGT	-DYADSVKGRFTISRDKAKNTVALQMNSLKPENTAVYYC--	56 - 93	38
CDR-H3	Chothia	--RAGWDLNRFDYRY	96 - 108	13
	AbM	--RAGWDLNRFDYRY	96 - 108	13
	Kabat	--RAGWDLNRFDYRY	96 - 108	13
	Contact	AARAGWDLNRFDYR-	94 - 107	14
	IMGT	AARAGWDLNRFDYRY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55311.1
Source	abYsis-EMBL-IG AM180321 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M207
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGRTFDNWTLGWFRQAPGKEREFVAAITWTGGVTDYADS
VKGRFTISRDKAKNTVALQMNSLKPENTAVYYCAARAGWDLNRFDYRYWGQGTQVT

DNA Sequence:

ctgcaggagtcagggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcaccttcgataactggaccctgggatggttccgccaggctccagggaag
gagcgtgagtttgtagcagctattacgtggactggtggtgtcacagactatgcagactcc
gtgaagggccgattcacgatctccagagacaaggccaagaacacggtggctctgcaaatg
aacagcctgaaacctgagaacacggccgtttattactgtgcagcgcgtgccggttgggac
cttaatagatttgattataggtactggggtcagggaacccaggtcacc

Data Source:

Alignment settings:

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