abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGRTFS	1 - 27	27
CDR-H1	SYTMA	28 - 32	5
HFR2	WFRQAPGKEREFVS	33 - 46	14
CDR-H2	IISWSDGNTYYADSVKG	47 - 63	17
HFR3	RFTISRDNAKNTVYLQMNSLKAEDTAVYYCAA	64 - 95	32
CDR-H3	DYSGLTTRWGAYDY	96 - 109	14
HFR4	WGQGTQVT	110 - 117	8
			117

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGRTFS	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGRTF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRTFSSY---	23 - 29	7
	AbM	GRTFSSYTMA	23 - 32	10
	Kabat	-----SYTMA	28 - 32	5
	Contact	----SSYTMA	27 - 32	6
	IMGT	GRTFSSYT--	23 - 30	8
HFR2	Chothia	TMAWFRQAPGKEREFVSII	30 - 48	19
	AbM	---WFRQAPGKEREFVS--	33 - 46	14
	Kabat	---WFRQAPGKEREFVS--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MAWFRQAPGKEREFVSI-	31 - 47	17
CDR-H2	Chothia	-----SWSDGN---------	49 - 54	6
	AbM	---IISWSDGNTY-------	47 - 56	10
	Kabat	---IISWSDGNTYYADSVKG	47 - 63	17
	Contact	FVSIISWSDGNTY-------	44 - 56	13
	IMGT	----ISWSDGNT--------	48 - 55	8
HFR3	Chothia	TYYADSVKGRFTISRDNAKNTVYLQMNSLKAEDTAVYYCAA	55 - 95	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLKAEDTAVYYCAA	57 - 95	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKAEDTAVYYCAA	64 - 95	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLKAEDTAVYYC--	57 - 93	37
	IMGT	-YYADSVKGRFTISRDNAKNTVYLQMNSLKAEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--DYSGLTTRWGAYDY	96 - 109	14
	AbM	--DYSGLTTRWGAYDY	96 - 109	14
	Kabat	--DYSGLTTRWGAYDY	96 - 109	14
	Contact	AADYSGLTTRWGAYD-	94 - 108	15
	IMGT	AADYSGLTTRWGAYDY	94 - 109	16
HFR4	Chothia	-WGQGTQVT	110 - 117	8
	AbM	-WGQGTQVT	110 - 117	8
	Kabat	-WGQGTQVT	110 - 117	8
	Contact	YWGQGTQVT	109 - 117	9
	IMGT	-WGQGTQVT	110 - 117	8

Accession & Annotations

Accession	CAJ55312.1
Source	abYsis-EMBL-IG AM180322 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M212
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGRTFSSYTMAWFRQAPGKEREFVSIISWSDGNTYYADS
VKGRFTISRDNAKNTVYLQMNSLKAEDTAVYYCAADYSGLTTRWGAYDYWGQGTQVT

DNA Sequence:

ctgcaggagtcagggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcaccttcagtagctataccatggcctggttccgccaggctccagggaag
gagcgtgagtttgtatcaattattagctggagtgatggtaacacatactatgcagactcc
gtgaagggccgattcaccatctccagagacaacgccaagaatacggtgtatctgcaaatg
aacagcctgaaagctgaggacacggccgtttattactgtgcagcagattattcgggactg
actacgcgttggggtgcgtacgactactggggacaggggacccaggtcacc

Data Source:

Alignment settings:

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