abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGRTFS	1 - 27	27
CDR-H1	GGAMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	AISWSGHSTYYGDSVKG	47 - 63	17
HFR3	RFTISRNNARNTVYLQMNSLKPEDTAVYYCNA	64 - 95	32
CDR-H3	RESAGWSSYRNY	96 - 107	12
HFR4	WGQGTQVT	108 - 115	8
			115

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGRTFS	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGRTF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRTFSGG---	23 - 29	7
	AbM	GRTFSGGAMG	23 - 32	10
	Kabat	-----GGAMG	28 - 32	5
	Contact	----SGGAMG	27 - 32	6
	IMGT	GRTFSGGA--	23 - 30	8
HFR2	Chothia	AMGWFRQAPGKEREFVAAI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAA-	31 - 47	17
CDR-H2	Chothia	-----SWSGHS---------	49 - 54	6
	AbM	---AISWSGHSTY-------	47 - 56	10
	Kabat	---AISWSGHSTYYGDSVKG	47 - 63	17
	Contact	FVAAISWSGHSTY-------	44 - 56	13
	IMGT	----ISWSGHST--------	48 - 55	8
HFR3	Chothia	TYYGDSVKGRFTISRNNARNTVYLQMNSLKPEDTAVYYCNA	55 - 95	41
	AbM	--YGDSVKGRFTISRNNARNTVYLQMNSLKPEDTAVYYCNA	57 - 95	39
	Kabat	---------RFTISRNNARNTVYLQMNSLKPEDTAVYYCNA	64 - 95	32
	Contact	--YGDSVKGRFTISRNNARNTVYLQMNSLKPEDTAVYYC--	57 - 93	37
	IMGT	-YYGDSVKGRFTISRNNARNTVYLQMNSLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--RESAGWSSYRNY	96 - 107	12
	AbM	--RESAGWSSYRNY	96 - 107	12
	Kabat	--RESAGWSSYRNY	96 - 107	12
	Contact	NARESAGWSSYRN-	94 - 106	13
	IMGT	NARESAGWSSYRNY	94 - 107	14
HFR4	Chothia	-WGQGTQVT	108 - 115	8
	AbM	-WGQGTQVT	108 - 115	8
	Kabat	-WGQGTQVT	108 - 115	8
	Contact	YWGQGTQVT	107 - 115	9
	IMGT	-WGQGTQVT	108 - 115	8

Accession & Annotations

Accession	CAJ55313.1
Source	abYsis-EMBL-IG AM180323 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M214
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGRTFSGGAMGWFRQAPGKEREFVAAISWSGHSTYYGDS
VKGRFTISRNNARNTVYLQMNSLKPEDTAVYYCNARESAGWSSYRNYWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgca
gcctctggacgcaccttcagtggaggtgccatgggctggttccgccaggctccagggaag
gagcgtgagtttgtagcagctattagctggagtggccatagcacatactatggagactcc
gtgaagggccgattcaccatctccagaaacaacgccaggaacacggtgtatctgcaaatg
aacagcctgaaacctgaggacacggccgtctattactgtaatgccagggaatcggcgggt
tggagtagctataggaactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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