abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGGSLRLSCAASGISFS	1 - 27	27
CDR-H1	IRDMG	28 - 32	5
HFR2	WYRQAPGKQRELVA	33 - 46	14
CDR-H2	TISSGGTTNYVDSVKG	47 - 62	16
HFR3	RFTISRDNAKVYLLMNILKPEDTAVYYCAV	63 - 92	30
CDR-H3	DWTTGWRTERS	93 - 103	11
HFR4	WGQGTQVT	104 - 111	8
			111

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGGSLRLSCAASGISFS	1 - 27	27
	Contact	LQESGGGLVQAGGSLRLSCAASGISF-	1 - 26	26
	IMGT	LQESGGGLVQAGGSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GISFSIR---	23 - 29	7
	AbM	GISFSIRDMG	23 - 32	10
	Kabat	-----IRDMG	28 - 32	5
	Contact	----SIRDMG	27 - 32	6
	IMGT	GISFSIRD--	23 - 30	8
HFR2	Chothia	DMGWYRQAPGKQRELVATI	30 - 48	19
	AbM	---WYRQAPGKQRELVA--	33 - 46	14
	Kabat	---WYRQAPGKQRELVA--	33 - 46	14
	Contact	---WYRQAPGKQRE-----	33 - 43	11
	IMGT	-MGWYRQAPGKQRELVAT-	31 - 47	17
CDR-H2	Chothia	-----SSGGT---------	49 - 53	5
	AbM	---TISSGGTTN-------	47 - 55	9
	Kabat	---TISSGGTTNYVDSVKG	47 - 62	16
	Contact	LVATISSGGTTN-------	44 - 55	12
	IMGT	----ISSGGTT--------	48 - 54	7
HFR3	Chothia	TNYVDSVKGRFTISRDNAKVYLLMNILKPEDTAVYYCAV	54 - 92	39
	AbM	--YVDSVKGRFTISRDNAKVYLLMNILKPEDTAVYYCAV	56 - 92	37
	Kabat	---------RFTISRDNAKVYLLMNILKPEDTAVYYCAV	63 - 92	30
	Contact	--YVDSVKGRFTISRDNAKVYLLMNILKPEDTAVYYC--	56 - 90	35
	IMGT	-NYVDSVKGRFTISRDNAKVYLLMNILKPEDTAVYYC--	55 - 90	36
CDR-H3	Chothia	--DWTTGWRTERS	93 - 103	11
	AbM	--DWTTGWRTERS	93 - 103	11
	Kabat	--DWTTGWRTERS	93 - 103	11
	Contact	AVDWTTGWRTER-	91 - 102	12
	IMGT	AVDWTTGWRTERS	91 - 103	13
HFR4	Chothia	-WGQGTQVT	104 - 111	8
	AbM	-WGQGTQVT	104 - 111	8
	Kabat	-WGQGTQVT	104 - 111	8
	Contact	SWGQGTQVT	103 - 111	9
	IMGT	-WGQGTQVT	104 - 111	8

Accession & Annotations

Accession	CAJ55314.1
Source	abYsis-EMBL-IG AM180324 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M217
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGGSLRLSCAASGISFSIRDMGWYRQAPGKQRELVATISSGGTTNYVDSV
KGRFTISRDNAKVYLLMNILKPEDTAVYYCAVDWTTGWRTERSWGQGTQVT

DNA Sequence:

ctgcaggagtctgggggaggcttggtgcaggctggggggtctctgaggctctcctgtgca
gcctctggaatcagcttcagtatccgtgacatgggctggtaccgccaggctccagggaag
cagcgcgagttggtcgcaactatttcgagtggtggcaccacaaactatgtagactccgtg
aagggccgattcaccatctccagagacaacgccaaggtgtatttgttgatgaacattctg
aaacctgaggacacagccgtctattactgcgcagtagattggactacgggttggcgtaca
gagaggtcctggggccaggggacgcaggtcacc

Data Source:

Alignment settings:

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