abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQESGGGLVQAGDSLRLSCAASGRTFS	1 - 27	27
CDR-H1	NYNMG	28 - 32	5
HFR2	WFRQAPGKEREFVA	33 - 46	14
CDR-H2	VIGWSGWSGGNPYYADSVKG	47 - 66	20
HFR3	RFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	67 - 98	32
CDR-H3	DRSLTRSASSYNY	99 - 111	13
HFR4	WGQGTQVT	112 - 119	8
			119

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQESGGGLVQAGDSLRLSCAAS-----	1 - 22	22
	AbM	LQESGGGLVQAGDSLRLSCAAS-----	1 - 22	22
	Kabat	LQESGGGLVQAGDSLRLSCAASGRTFS	1 - 27	27
	Contact	LQESGGGLVQAGDSLRLSCAASGRTF-	1 - 26	26
	IMGT	LQESGGGLVQAGDSLRLSCAAS-----	1 - 22	22
CDR-H1	Chothia	GRTFSNY---	23 - 29	7
	AbM	GRTFSNYNMG	23 - 32	10
	Kabat	-----NYNMG	28 - 32	5
	Contact	----SNYNMG	27 - 32	6
	IMGT	GRTFSNYN--	23 - 30	8
HFR2	Chothia	NMGWFRQAPGKEREFVAVI	30 - 48	19
	AbM	---WFRQAPGKEREFVA--	33 - 46	14
	Kabat	---WFRQAPGKEREFVA--	33 - 46	14
	Contact	---WFRQAPGKERE-----	33 - 43	11
	IMGT	-MGWFRQAPGKEREFVAV-	31 - 47	17
CDR-H2	Chothia	-----GWSGWSGGN---------	49 - 57	9
	AbM	---VIGWSGWSGGNPY-------	47 - 59	13
	Kabat	---VIGWSGWSGGNPYYADSVKG	47 - 66	20
	Contact	FVAVIGWSGWSGGNPY-------	44 - 59	16
	IMGT	----IGWSGWSGGNP--------	48 - 58	11
HFR3	Chothia	PYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	58 - 98	41
	AbM	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	60 - 98	39
	Kabat	---------RFTISRDNAKNTVYLQMNSLKPEDTAVYYCAA	67 - 98	32
	Contact	--YADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	60 - 96	37
	IMGT	-YYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYC--	59 - 96	38
CDR-H3	Chothia	--DRSLTRSASSYNY	99 - 111	13
	AbM	--DRSLTRSASSYNY	99 - 111	13
	Kabat	--DRSLTRSASSYNY	99 - 111	13
	Contact	AADRSLTRSASSYN-	97 - 110	14
	IMGT	AADRSLTRSASSYNY	97 - 111	15
HFR4	Chothia	-WGQGTQVT	112 - 119	8
	AbM	-WGQGTQVT	112 - 119	8
	Kabat	-WGQGTQVT	112 - 119	8
	Contact	YWGQGTQVT	111 - 119	9
	IMGT	-WGQGTQVT	112 - 119	8

Accession & Annotations

Accession	CAJ55315.1
Source	abYsis-EMBL-IG AM180325 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M218
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQESGGGLVQAGDSLRLSCAASGRTFSNYNMGWFRQAPGKEREFVAVIGWSGWSGGNPYY
ADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAADRSLTRSASSYNYWGQGTQVT

DNA Sequence:

ctgcaggagtcagggggaggattggtgcaggctggggactctctgagactctcctgtgca
gcctctggacgcaccttcagtaactataacatgggctggttccgccaggctccagggaag
gagcgtgagtttgtcgcagttattggttggagtggttggagtggtggtaacccatactat
gccgactccgtgaagggccgattcaccatctccagagacaacgccaagaacacggtgtat
ctgcaaatgaacagcctgaaacctgaggacacggccgtttattactgtgcagcagatcgg
agtctgacgcggtcggcgtcaagctataactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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