abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
HFR1	LQQSGGGLVQAGGSLRLSCATSGRTFN	1 - 27	27
CDR-H1	SYNMG	28 - 32	5
HFR2	WFRQSPGKEREFVA	33 - 46	14
CDR-H2	LTSWYDSSTNYADSLKG	47 - 63	17
HFR3	RFTISRDNAKNTMYLQMDSLKPEDTAVYYCAA	64 - 95	32
CDR-H3	GRSYSSNPAAYNY	96 - 108	13
HFR4	WGQGTQVT	109 - 116	8
			116

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	LQQSGGGLVQAGGSLRLSCATS-----	1 - 22	22
	AbM	LQQSGGGLVQAGGSLRLSCATS-----	1 - 22	22
	Kabat	LQQSGGGLVQAGGSLRLSCATSGRTFN	1 - 27	27
	Contact	LQQSGGGLVQAGGSLRLSCATSGRTF-	1 - 26	26
	IMGT	LQQSGGGLVQAGGSLRLSCATS-----	1 - 22	22
CDR-H1	Chothia	GRTFNSY---	23 - 29	7
	AbM	GRTFNSYNMG	23 - 32	10
	Kabat	-----SYNMG	28 - 32	5
	Contact	----NSYNMG	27 - 32	6
	IMGT	GRTFNSYN--	23 - 30	8
HFR2	Chothia	NMGWFRQSPGKEREFVALT	30 - 48	19
	AbM	---WFRQSPGKEREFVA--	33 - 46	14
	Kabat	---WFRQSPGKEREFVA--	33 - 46	14
	Contact	---WFRQSPGKERE-----	33 - 43	11
	IMGT	-MGWFRQSPGKEREFVAL-	31 - 47	17
CDR-H2	Chothia	-----SWYDSS---------	49 - 54	6
	AbM	---LTSWYDSSTN-------	47 - 56	10
	Kabat	---LTSWYDSSTNYADSLKG	47 - 63	17
	Contact	FVALTSWYDSSTN-------	44 - 56	13
	IMGT	----TSWYDSST--------	48 - 55	8
HFR3	Chothia	TNYADSLKGRFTISRDNAKNTMYLQMDSLKPEDTAVYYCAA	55 - 95	41
	AbM	--YADSLKGRFTISRDNAKNTMYLQMDSLKPEDTAVYYCAA	57 - 95	39
	Kabat	---------RFTISRDNAKNTMYLQMDSLKPEDTAVYYCAA	64 - 95	32
	Contact	--YADSLKGRFTISRDNAKNTMYLQMDSLKPEDTAVYYC--	57 - 93	37
	IMGT	-NYADSLKGRFTISRDNAKNTMYLQMDSLKPEDTAVYYC--	56 - 93	38
CDR-H3	Chothia	--GRSYSSNPAAYNY	96 - 108	13
	AbM	--GRSYSSNPAAYNY	96 - 108	13
	Kabat	--GRSYSSNPAAYNY	96 - 108	13
	Contact	AAGRSYSSNPAAYN-	94 - 107	14
	IMGT	AAGRSYSSNPAAYNY	94 - 108	15
HFR4	Chothia	-WGQGTQVT	109 - 116	8
	AbM	-WGQGTQVT	109 - 116	8
	Kabat	-WGQGTQVT	109 - 116	8
	Contact	YWGQGTQVT	108 - 116	9
	IMGT	-WGQGTQVT	109 - 116	8

Accession & Annotations

Accession	CAJ55316.1
Source	abYsis-EMBL-IG AM180326 Submitted 20-DEC-2005 Updated 27-FEB-2007
Name	immunoglobulin heavy chain variable region
Clone	M219
Organism	Lama glama
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	Harmsen M.M. Submitted (16-DEC-2005) to the INSDC. Harmsen M.M., Infection Biology, Animal Sciences Group (ID-Lelystad BV), Edelhertweg 15, Lelystad, 8219 PH, NETHERLANDS. Harmsen M.M., van Solt C.B., Fijten H.P.D., van Keulen L., Rosalia R.A., Weerdmeester K., Cornelissen .A.H.M., De Bruin M.G.M., Eble P.L., Dekker A. 'Passive immunization of guinea pigs with llama single-domain antibody fragments against foot-and-mouth disease' Vet. Microbiol. 120(3-4):193-206(2007).

Tools

Sequences

Amino Acid Sequence:

LQQSGGGLVQAGGSLRLSCATSGRTFNSYNMGWFRQSPGKEREFVALTSWYDSSTNYADS
LKGRFTISRDNAKNTMYLQMDSLKPEDTAVYYCAAGRSYSSNPAAYNYWGQGTQVT

DNA Sequence:

ctgcagcagtctgggggaggattggtgcaggctgggggctctctgagactctcctgtgca
acctctggacgcaccttcaatagctataacatgggctggttccgccagtctccagggaag
gagcgtgagtttgtagcgcttactagttggtatgatagtagcacaaactatgcagactcc
ttgaagggccgattcaccatctccagagacaacgccaaaaacacgatgtatctgcaaatg
gacagcctgaaacctgaggacacggccgtttattactgtgcagcggggcgctcgtacagt
agtaacccggccgcctataactactggggccaggggacccaggtcacc

Data Source:

Alignment settings:

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