abYsis

Numbering & Regions

Comparison Organism:

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Region Sequence Details

Regions Definition

Region	Sequence Fragment	Residues	Length
Leader	MA	1 - 2	2
HFR1	DVQLQESGGGSVQAGGSLRLSCVASGVTST	3 - 32	30
CDR-H1	RPCIG	33 - 37	5
HFR2	WFRQAPGKEREGVA	38 - 51	14
CDR-H2	VVNFRGDSTYITDSVKG	52 - 68	17
HFR3	RFTISRDEDSDTVYLQMNSLKPEDTATYYCAA	69 - 100	32
CDR-H3	DVNRGGFCYIEDWYFSY	101 - 117	17
HFR4	WGQGTQVTVSS	118 - 128	11
Tail	AAAHHHHHH	128 - 137	9
			137

Region	Definition	Sequence Fragment	Residues	Length
HFR1	Chothia	DVQLQESGGGSVQAGGSLRLSCVAS-----	3 - 27	25
	AbM	DVQLQESGGGSVQAGGSLRLSCVAS-----	3 - 27	25
	Kabat	DVQLQESGGGSVQAGGSLRLSCVASGVTST	3 - 32	30
	Contact	DVQLQESGGGSVQAGGSLRLSCVASGVTS-	3 - 31	29
	IMGT	DVQLQESGGGSVQAGGSLRLSCVAS-----	3 - 27	25
CDR-H1	Chothia	GVTSTRP---	28 - 34	7
	AbM	GVTSTRPCIG	28 - 37	10
	Kabat	-----RPCIG	33 - 37	5
	Contact	----TRPCIG	32 - 37	6
	IMGT	GVTSTRPC--	28 - 35	8
HFR2	Chothia	CIGWFRQAPGKEREGVAVV	35 - 53	19
	AbM	---WFRQAPGKEREGVA--	38 - 51	14
	Kabat	---WFRQAPGKEREGVA--	38 - 51	14
	Contact	---WFRQAPGKERE-----	38 - 48	11
	IMGT	-IGWFRQAPGKEREGVAV-	36 - 52	17
CDR-H2	Chothia	-----NFRGDS---------	54 - 59	6
	AbM	---VVNFRGDSTY-------	52 - 61	10
	Kabat	---VVNFRGDSTYITDSVKG	52 - 68	17
	Contact	GVAVVNFRGDSTY-------	49 - 61	13
	IMGT	----VNFRGDST--------	53 - 60	8
HFR3	Chothia	TYITDSVKGRFTISRDEDSDTVYLQMNSLKPEDTATYYCAA	60 - 100	41
	AbM	--ITDSVKGRFTISRDEDSDTVYLQMNSLKPEDTATYYCAA	62 - 100	39
	Kabat	---------RFTISRDEDSDTVYLQMNSLKPEDTATYYCAA	69 - 100	32
	Contact	--ITDSVKGRFTISRDEDSDTVYLQMNSLKPEDTATYYC--	62 - 98	37
	IMGT	-YITDSVKGRFTISRDEDSDTVYLQMNSLKPEDTATYYC--	61 - 98	38
CDR-H3	Chothia	--DVNRGGFCYIEDWYFSY	101 - 117	17
	AbM	--DVNRGGFCYIEDWYFSY	101 - 117	17
	Kabat	--DVNRGGFCYIEDWYFSY	101 - 117	17
	Contact	AADVNRGGFCYIEDWYFS-	99 - 116	18
	IMGT	AADVNRGGFCYIEDWYFSY	99 - 117	19
HFR4	Chothia	-WGQGTQVTVSS	118 - 128	11
	AbM	-WGQGTQVTVSS	118 - 128	11
	Kabat	-WGQGTQVTVSS	118 - 128	11
	Contact	YWGQGTQVTVSS	117 - 128	12
	IMGT	-WGQGTQVTVSS	118 - 128	11

Accession & Annotations

Accession	5u64_B
Source	PDB 5u64 Submitted 07-DEC-2016 Updated 20-SEP-2017
Name	CAMEL NANOBODY VHH-28
Organism	Camelus dromedarius
Chain Type	Heavy
Pairing	None
Identical Protein Sequences	None
References	KOCH K., KALUSCHE S., TORRES L., STANFIELD L., DANQUAH W., KHAZANEHDARI K., VON BRIESEN H., GEERTSMA R., WILSON A., WERNERY U., KOCH-NOLTE F., WARD B., DIETRICH U. 'SELECTION OF NANOBODIES WITH BROAD NEUTRALIZING POTENTIAL AGAINST PRIMARY HIV-1 STRAINS USING SOLUBLE SUBTYPE C GP140 ENVELOPE TRIMERS.' SCI REP V. 7 8390 2017 ESSN 2045-2322

Tools

Sequences

Amino Acid Sequence:

MADVQLQESGGGSVQAGGSLRLSCVASGVTSTRPCIGWFRQAPGKEREGVAVVNFRGDST
YITDSVKGRFTISRDEDSDTVYLQMNSLKPEDTATYYCAADVNRGGFCYIEDWYFSYWGQ
GTQVTVSSAAAHHHHHH